Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy

Targeting STAT3 and STAT5 in Tumor-Associated Immune Cells to Improve Immunotherapy

Oncogene-induced STAT3-activation is central to tumor progression by promoting cancer cell expression of pro-angiogenic and immunosuppressive factors. STAT3 is also activated in infiltrating immune cells including tumor-associated macrophages (TAM) amplifying immune suppression. Consequently, STAT3...

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Bibliographic Details
Main Authors: Grégory Verdeil, Toby Lawrence, Anne-Marie Schmitt-Verhulst, Nathalie Auphan-Anezin
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
inflammation
tumor-associated macrophages
adoptive t cell therapy
immune suppression
stat transcription factors
Online Access:https://www.mdpi.com/2072-6694/11/12/1832

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