Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyoderma
Background and Aim: Pyoderma is common in dogs, and its treatment requires a novel medication rather than antibiotic therapy. This study aimed to determine the biochemical and histopathological changes associated with the topical application of Aloe vera 20% and 40% ointments, compared with gentamic...
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| Format: | Article |
| Language: | English |
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Veterinary World
2021-05-01
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| Series: | Veterinary World |
| Subjects: | |
| Online Access: | http://www.veterinaryworld.org/Vol.14/May-2021/38.pdf |
| _version_ | 1818365911852122112 |
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| author | Ali Arbaga Amanallah El-Bahrawy Ahmed Elsify Hadeer Khaled Hany Youssef Hassan Ahmed Kamr |
| author_facet | Ali Arbaga Amanallah El-Bahrawy Ahmed Elsify Hadeer Khaled Hany Youssef Hassan Ahmed Kamr |
| author_sort | Ali Arbaga |
| collection | DOAJ |
| description | Background and Aim: Pyoderma is common in dogs, and its treatment requires a novel medication rather than antibiotic therapy. This study aimed to determine the biochemical and histopathological changes associated with the topical application of Aloe vera 20% and 40% ointments, compared with gentamicin 0.1% ointment, in dogs suffering from Staphylococcus aureus pyoderma.
Materials and Methods: Serum and skin samples were collected from a negative control group before inducing pyoderma and from other subdivided groups on the 3rd, 7th, 10th, and 14th days post-inoculation for biochemical and histopathology examination.
Results: Serum aspartate aminotransferase, alanine aminotransferase (ALT), urea, and creatinine concentrations were higher in the positive control dogs on the 3rd day without treatment (DWT) compared with the negative control dogs (p<0.05). Compared with the healthy control dogs, serum zinc concentrations were lower in the positive control group on the 3rd, 7th, and 10th DWT and in dogs treated with A. vera 20% and gentamicin 0.1% ointments on the 3rd and 7th days post-treatment (p<0.05). Grossly, skin had erythema, pruritus, and pus-filled pustules of the untreated group. Microscopically, skin showed epidermal necrosis and edema, dermal collagen necrosis, and severe neutrophilic infiltration.
Conclusion: Compared with A. vera 20% and gentamicin 0.1% ointments, the topical application of A. vera 40% ointmentinduced quicker skin healing and decreased the inflammatory changes caused by S. aureus inoculation, based on biochemical and histopathological changes reflective of its curative efficiency. A. vera 40% ointment may be a suitable alternative to antibiotics for the treatment of staphylococcal pyoderma in dogs. |
| first_indexed | 2024-12-13T22:27:47Z |
| format | Article |
| id | doaj.art-dce49d74aa9d4f828756b5bb750d0f22 |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-13T22:27:47Z |
| publishDate | 2021-05-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-dce49d74aa9d4f828756b5bb750d0f222022-12-21T23:29:09ZengVeterinary WorldVeterinary World0972-89882231-09162021-05-011451354136210.14202/vetworld.2021.1354-1362Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyodermaAli Arbaga0https://orcid.org/0000-0001-5634-6041Amanallah El-Bahrawy1https://orcid.org/0000-0001-7653-0081Ahmed Elsify2https://orcid.org/0000-0003-0660-9071Hadeer Khaled3https://orcid.org/0000-0002-5660-5979Hany Youssef Hassan4https://orcid.org/0000-0002-6363-8808Ahmed Kamr5https://orcid.org/0000-0002-7409-0227Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.Department of Animal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, University of Sadat City, Sadat City, Egypt.Background and Aim: Pyoderma is common in dogs, and its treatment requires a novel medication rather than antibiotic therapy. This study aimed to determine the biochemical and histopathological changes associated with the topical application of Aloe vera 20% and 40% ointments, compared with gentamicin 0.1% ointment, in dogs suffering from Staphylococcus aureus pyoderma. Materials and Methods: Serum and skin samples were collected from a negative control group before inducing pyoderma and from other subdivided groups on the 3rd, 7th, 10th, and 14th days post-inoculation for biochemical and histopathology examination. Results: Serum aspartate aminotransferase, alanine aminotransferase (ALT), urea, and creatinine concentrations were higher in the positive control dogs on the 3rd day without treatment (DWT) compared with the negative control dogs (p<0.05). Compared with the healthy control dogs, serum zinc concentrations were lower in the positive control group on the 3rd, 7th, and 10th DWT and in dogs treated with A. vera 20% and gentamicin 0.1% ointments on the 3rd and 7th days post-treatment (p<0.05). Grossly, skin had erythema, pruritus, and pus-filled pustules of the untreated group. Microscopically, skin showed epidermal necrosis and edema, dermal collagen necrosis, and severe neutrophilic infiltration. Conclusion: Compared with A. vera 20% and gentamicin 0.1% ointments, the topical application of A. vera 40% ointmentinduced quicker skin healing and decreased the inflammatory changes caused by S. aureus inoculation, based on biochemical and histopathological changes reflective of its curative efficiency. A. vera 40% ointment may be a suitable alternative to antibiotics for the treatment of staphylococcal pyoderma in dogs.http://www.veterinaryworld.org/Vol.14/May-2021/38.pdfaloe vera biochemical and histopathology examinationgentamicinpyodermastaphylococcus aureus |
| spellingShingle | Ali Arbaga Amanallah El-Bahrawy Ahmed Elsify Hadeer Khaled Hany Youssef Hassan Ahmed Kamr Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyoderma Veterinary World aloe vera biochemical and histopathology examination gentamicin pyoderma staphylococcus aureus |
| title | Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyoderma |
| title_full | Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyoderma |
| title_fullStr | Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyoderma |
| title_full_unstemmed | Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyoderma |
| title_short | Biochemical and histopathological changes related to the topical application of Aloe vera ointment for canine pyoderma |
| title_sort | biochemical and histopathological changes related to the topical application of aloe vera ointment for canine pyoderma |
| topic | aloe vera biochemical and histopathology examination gentamicin pyoderma staphylococcus aureus |
| url | http://www.veterinaryworld.org/Vol.14/May-2021/38.pdf |
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