Cortical amyloid burden and age moderate hippocampal activity in cognitively-normal adults

Cortical amyloid burden and age moderate hippocampal activity in cognitively-normal adults

Neurodegeneration in the medial temporal lobe, particularly in the hippocampus, is viewed as the primary source of AD-related memory deficits. Yet, in the earliest preclinical phase of Alzheimer's disease (AD), amyloid-beta (Aβ) plaques deposit primarily in the neocortex, not in the medial temp...

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Bibliographic Details
Main Authors: Zhuang Song, Ian M. McDonough, Peiying Liu, Hanzhang Lu, Denise C. Park
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:NeuroImage: Clinical
Subjects:
Amyloid
Hippocampus
Age
Preclinical Alzheimer's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158216300894

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