Gut microbiome and its role in colorectal cancer
Abstract Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and the gut microbiome plays an important role in its development. The microbiome is involved in the carcinogenesis, formation and progression of CRC as well as its response to different systemic therapies...
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| Format: | Article |
| Language: | English |
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BMC
2021-12-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-021-09054-2 |
| _version_ | 1818402148864491520 |
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| author | Martina Rebersek |
| author_facet | Martina Rebersek |
| author_sort | Martina Rebersek |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and the gut microbiome plays an important role in its development. The microbiome is involved in the carcinogenesis, formation and progression of CRC as well as its response to different systemic therapies. The composition of bacterial strains and the influence of geography, race, sex, and diet on the composition of the microbiome serve as important information for screening, early detection and prediction of the treatment outcome of CRC. Microbiome modulation is one of the most prospective new strategies in medicine to improve the health of individuals. Therefore, future research and clinical trials on the gut microbiome in oncology as well as in the treatment of CRC patients are warranted to determine the efficacy of systemic treatments for CRC, minimize adverse effects and increase survival rates. |
| first_indexed | 2024-12-14T08:03:46Z |
| format | Article |
| id | doaj.art-dce55553492349c98281926d300b395b |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-14T08:03:46Z |
| publishDate | 2021-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-dce55553492349c98281926d300b395b2022-12-21T23:10:16ZengBMCBMC Cancer1471-24072021-12-0121111310.1186/s12885-021-09054-2Gut microbiome and its role in colorectal cancerMartina Rebersek0Department of Medical Oncology, Institute of Oncology LjubljanaAbstract Colorectal cancer (CRC) is still one of the most common types of cancer in the world, and the gut microbiome plays an important role in its development. The microbiome is involved in the carcinogenesis, formation and progression of CRC as well as its response to different systemic therapies. The composition of bacterial strains and the influence of geography, race, sex, and diet on the composition of the microbiome serve as important information for screening, early detection and prediction of the treatment outcome of CRC. Microbiome modulation is one of the most prospective new strategies in medicine to improve the health of individuals. Therefore, future research and clinical trials on the gut microbiome in oncology as well as in the treatment of CRC patients are warranted to determine the efficacy of systemic treatments for CRC, minimize adverse effects and increase survival rates.https://doi.org/10.1186/s12885-021-09054-2Gut microbiomeColorectal cancerPrognostic and predictive biomarkersModulation of gut microbiomeSystemic treatment of CRC |
| spellingShingle | Martina Rebersek Gut microbiome and its role in colorectal cancer BMC Cancer Gut microbiome Colorectal cancer Prognostic and predictive biomarkers Modulation of gut microbiome Systemic treatment of CRC |
| title | Gut microbiome and its role in colorectal cancer |
| title_full | Gut microbiome and its role in colorectal cancer |
| title_fullStr | Gut microbiome and its role in colorectal cancer |
| title_full_unstemmed | Gut microbiome and its role in colorectal cancer |
| title_short | Gut microbiome and its role in colorectal cancer |
| title_sort | gut microbiome and its role in colorectal cancer |
| topic | Gut microbiome Colorectal cancer Prognostic and predictive biomarkers Modulation of gut microbiome Systemic treatment of CRC |
| url | https://doi.org/10.1186/s12885-021-09054-2 |
| work_keys_str_mv | AT martinarebersek gutmicrobiomeanditsroleincolorectalcancer |