CACNA1C rs1006737, Threatening Life Events, and Gene–Environment Interaction Predict Major Depressive Disorder
IntroductionCACNA1C rs1006737 is a novel variant in discovery of replicable associations in major depressive disorder (MDD). However, there have been no specific studies considered effect of environmental pathogens to date examining its clinical significance. In this study we investigated the intera...
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Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00982/full |
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| author | Mingzhe Zhao Jiarun Yang Xiaohui Qiu Xiuxian Yang Zhengxue Qiao Xuejia Song Lin Wang Erying Zhao Yanjie Yang Depin Cao |
| author_facet | Mingzhe Zhao Jiarun Yang Xiaohui Qiu Xiuxian Yang Zhengxue Qiao Xuejia Song Lin Wang Erying Zhao Yanjie Yang Depin Cao |
| author_sort | Mingzhe Zhao |
| collection | DOAJ |
| description | IntroductionCACNA1C rs1006737 is a novel variant in discovery of replicable associations in major depressive disorder (MDD). However, there have been no specific studies considered effect of environmental pathogens to date examining its clinical significance. In this study we investigated the interaction effect between CACNA1C rs1006737 polymorphism and threatening life events (TLEs) in MDD and carried out a meta-analysis of published findings.MethodsA total of 1,177 consecutive participants were genotyped. Information on exposure to TLEs, socio-demographic data, and history of psychological problems among first-degree relatives was collected. MDD was diagnosed according to the Chinese version of the 24-item Hamilton Rating Scale for Depression.ResultsThere was a significant interaction effect between CACNA1C rs1006737 polymorphism and TLEs in MDD. A dose–response relationship was found between CACNA1C rs1006737 genotypes and TLEs in MDD. The results of the meta-analysis showed that CACNA1C rs1006737 genotypes interacted with TLEs in MDD.ConclusionCACNA1C rs1006737 genotype and previous exposure to TLEs interact to influence the risk of developing MDD. We propose that CACNA1C rs1006737 may represent a target for novel pharmacological therapies to prevent or treat MDD. |
| first_indexed | 2024-04-13T10:04:42Z |
| format | Article |
| id | doaj.art-dce64e140fb94f8296a75386aae83c41 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T10:04:42Z |
| publishDate | 2020-01-01 |
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| series | Frontiers in Psychiatry |
| spelling | doaj.art-dce64e140fb94f8296a75386aae83c412022-12-22T02:51:08ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-01-011010.3389/fpsyt.2019.00982496732CACNA1C rs1006737, Threatening Life Events, and Gene–Environment Interaction Predict Major Depressive DisorderMingzhe Zhao0Jiarun Yang1Xiaohui Qiu2Xiuxian Yang3Zhengxue Qiao4Xuejia Song5Lin Wang6Erying Zhao7Yanjie Yang8Depin Cao9Psychology Department of the Public Health Institute of Harbin Medical University, Harbin, ChinaDepartment of Health Management of Harbin Medical University, Harbin, ChinaPsychology Department of the Public Health Institute of Harbin Medical University, Harbin, ChinaPsychology Department of the Public Health Institute of Harbin Medical University, Harbin, ChinaPsychology Department of the Public Health Institute of Harbin Medical University, Harbin, ChinaPsychology Department of the Public Health Institute of Harbin Medical University, Harbin, ChinaPsychology Department of the Public Health Institute of Harbin Medical University, Harbin, ChinaPsychology Department of the Public Health Institute of Harbin Medical University, Harbin, ChinaPsychology Department of the Public Health Institute of Harbin Medical University, Harbin, ChinaDepartment of Health Management of Harbin Medical University, Harbin, ChinaIntroductionCACNA1C rs1006737 is a novel variant in discovery of replicable associations in major depressive disorder (MDD). However, there have been no specific studies considered effect of environmental pathogens to date examining its clinical significance. In this study we investigated the interaction effect between CACNA1C rs1006737 polymorphism and threatening life events (TLEs) in MDD and carried out a meta-analysis of published findings.MethodsA total of 1,177 consecutive participants were genotyped. Information on exposure to TLEs, socio-demographic data, and history of psychological problems among first-degree relatives was collected. MDD was diagnosed according to the Chinese version of the 24-item Hamilton Rating Scale for Depression.ResultsThere was a significant interaction effect between CACNA1C rs1006737 polymorphism and TLEs in MDD. A dose–response relationship was found between CACNA1C rs1006737 genotypes and TLEs in MDD. The results of the meta-analysis showed that CACNA1C rs1006737 genotypes interacted with TLEs in MDD.ConclusionCACNA1C rs1006737 genotype and previous exposure to TLEs interact to influence the risk of developing MDD. We propose that CACNA1C rs1006737 may represent a target for novel pharmacological therapies to prevent or treat MDD.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00982/fullCACNA1Cpolymorphismthreatening life eventsgene–environment interactionmajor depressive disorder |
| spellingShingle | Mingzhe Zhao Jiarun Yang Xiaohui Qiu Xiuxian Yang Zhengxue Qiao Xuejia Song Lin Wang Erying Zhao Yanjie Yang Depin Cao CACNA1C rs1006737, Threatening Life Events, and Gene–Environment Interaction Predict Major Depressive Disorder Frontiers in Psychiatry CACNA1C polymorphism threatening life events gene–environment interaction major depressive disorder |
| title | CACNA1C rs1006737, Threatening Life Events, and Gene–Environment Interaction Predict Major Depressive Disorder |
| title_full | CACNA1C rs1006737, Threatening Life Events, and Gene–Environment Interaction Predict Major Depressive Disorder |
| title_fullStr | CACNA1C rs1006737, Threatening Life Events, and Gene–Environment Interaction Predict Major Depressive Disorder |
| title_full_unstemmed | CACNA1C rs1006737, Threatening Life Events, and Gene–Environment Interaction Predict Major Depressive Disorder |
| title_short | CACNA1C rs1006737, Threatening Life Events, and Gene–Environment Interaction Predict Major Depressive Disorder |
| title_sort | cacna1c rs1006737 threatening life events and gene environment interaction predict major depressive disorder |
| topic | CACNA1C polymorphism threatening life events gene–environment interaction major depressive disorder |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00982/full |
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