Neurological manifestations and mortality in hospitalized coronavirus disease 2019 patients
Purpose: The purpose of the study is to analyze the neurological manifestations and to determine the association between these symptoms and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19). Materials and Methods: Five hundred and forty-seven hospitalized patients with posi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Neurological Sciences and Neurophysiology |
| Subjects: | |
| Online Access: | http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2022;volume=39;issue=3;spage=138;epage=145;aulast=Ozel |
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| author | Tugba Ozel Nazan Şimşek Erdem Ali Ünal Ata Nevzat Yalçın Dilara İnan Nevruz Ilhanli Hilmi Uysal |
| author_facet | Tugba Ozel Nazan Şimşek Erdem Ali Ünal Ata Nevzat Yalçın Dilara İnan Nevruz Ilhanli Hilmi Uysal |
| author_sort | Tugba Ozel |
| collection | DOAJ |
| description | Purpose: The purpose of the study is to analyze the neurological manifestations and to determine the association between these symptoms and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19). Materials and Methods: Five hundred and forty-seven hospitalized patients with positive reverse transcriptase-polymerase chain reaction tests for severe acute respiratory syndrome coronavirus in a nasopharyngeal swab were included in this study. The demographic features, laboratory data, and radiologic imaging, neurological symptoms of hospitalized patients with COVID-19 were collected. Results: Of 547 hospitalized COVID-19 patients, the median age was 61 (range 18–93), 61.4% were male. Three hundred and forty-seven (63.4%) patients had a severe infection and 200 (36.6%) patients had a mild infection. Eighty-eight patients (16.1%) died during hospitalization. One hundred and fifty-four (28.2%) patients had at least one neurological symptom. Thirty-five (6.4%) patients manifested with only neurological symptoms at hospital admission. The most frequent neurological symptoms were headache (15.2%), taste and smell disorders (9.1%), and myalgia (6.6%). The other initial neurological manifestations were acute cerebral ischemic stroke, impaired consciousness, epileptic seizure, and posterior reversible encephalopathy. The late-onset neurological complications were autoimmune encephalitis and Guillain-Barre syndrome. The neurological manifestation was linked to the severity of disease (P = 0.005) but not correlated with mortality (P = 0.137). Conclusion: Neurological symptoms were frequent in COVID-19 patients. The neurological symptoms can be the initial symptoms or can be late-onset complications of COVID-19. |
| first_indexed | 2024-04-11T17:17:25Z |
| format | Article |
| id | doaj.art-dce775c5f18f4aa49dc08354deafc9fe |
| institution | Directory Open Access Journal |
| issn | 2636-865X |
| language | English |
| last_indexed | 2024-04-11T17:17:25Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neurological Sciences and Neurophysiology |
| spelling | doaj.art-dce775c5f18f4aa49dc08354deafc9fe2022-12-22T04:12:36ZengWolters Kluwer Medknow PublicationsNeurological Sciences and Neurophysiology2636-865X2022-01-0139313814510.4103/nsn.nsn_117_21Neurological manifestations and mortality in hospitalized coronavirus disease 2019 patientsTugba OzelNazan Şimşek ErdemAli ÜnalAta Nevzat YalçınDilara İnanNevruz IlhanliHilmi UysalPurpose: The purpose of the study is to analyze the neurological manifestations and to determine the association between these symptoms and mortality in hospitalized patients with coronavirus disease 2019 (COVID-19). Materials and Methods: Five hundred and forty-seven hospitalized patients with positive reverse transcriptase-polymerase chain reaction tests for severe acute respiratory syndrome coronavirus in a nasopharyngeal swab were included in this study. The demographic features, laboratory data, and radiologic imaging, neurological symptoms of hospitalized patients with COVID-19 were collected. Results: Of 547 hospitalized COVID-19 patients, the median age was 61 (range 18–93), 61.4% were male. Three hundred and forty-seven (63.4%) patients had a severe infection and 200 (36.6%) patients had a mild infection. Eighty-eight patients (16.1%) died during hospitalization. One hundred and fifty-four (28.2%) patients had at least one neurological symptom. Thirty-five (6.4%) patients manifested with only neurological symptoms at hospital admission. The most frequent neurological symptoms were headache (15.2%), taste and smell disorders (9.1%), and myalgia (6.6%). The other initial neurological manifestations were acute cerebral ischemic stroke, impaired consciousness, epileptic seizure, and posterior reversible encephalopathy. The late-onset neurological complications were autoimmune encephalitis and Guillain-Barre syndrome. The neurological manifestation was linked to the severity of disease (P = 0.005) but not correlated with mortality (P = 0.137). Conclusion: Neurological symptoms were frequent in COVID-19 patients. The neurological symptoms can be the initial symptoms or can be late-onset complications of COVID-19.http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2022;volume=39;issue=3;spage=138;epage=145;aulast=Ozelautoimmune encephalitiscoronavirus disease 2019late-onset complicationmortalityneurologic manifestationssensorineural hearing loss |
| spellingShingle | Tugba Ozel Nazan Şimşek Erdem Ali Ünal Ata Nevzat Yalçın Dilara İnan Nevruz Ilhanli Hilmi Uysal Neurological manifestations and mortality in hospitalized coronavirus disease 2019 patients Neurological Sciences and Neurophysiology autoimmune encephalitis coronavirus disease 2019 late-onset complication mortality neurologic manifestations sensorineural hearing loss |
| title | Neurological manifestations and mortality in hospitalized coronavirus disease 2019 patients |
| title_full | Neurological manifestations and mortality in hospitalized coronavirus disease 2019 patients |
| title_fullStr | Neurological manifestations and mortality in hospitalized coronavirus disease 2019 patients |
| title_full_unstemmed | Neurological manifestations and mortality in hospitalized coronavirus disease 2019 patients |
| title_short | Neurological manifestations and mortality in hospitalized coronavirus disease 2019 patients |
| title_sort | neurological manifestations and mortality in hospitalized coronavirus disease 2019 patients |
| topic | autoimmune encephalitis coronavirus disease 2019 late-onset complication mortality neurologic manifestations sensorineural hearing loss |
| url | http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2022;volume=39;issue=3;spage=138;epage=145;aulast=Ozel |
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