Epigenetics: a possible role in acute and transgenerational regulation of dairy cow milk production
A potential role for epigenetic mechanisms in the regulation of mammary function in the dairy cow is emerging. Epigenetics is the study of heritable changes in genome function that occur because of chemical changes rather than DNA sequence changes. DNA methylation is an epigenetic event that results...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2012-01-01
|
| Series: | Animal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1751731111002564 |
| _version_ | 1818431160920834048 |
|---|---|
| author | K. Singh A.J. Molenaar K.M. Swanson B. Gudex J.A. Arias R.A. Erdman K. Stelwagen |
| author_facet | K. Singh A.J. Molenaar K.M. Swanson B. Gudex J.A. Arias R.A. Erdman K. Stelwagen |
| author_sort | K. Singh |
| collection | DOAJ |
| description | A potential role for epigenetic mechanisms in the regulation of mammary function in the dairy cow is emerging. Epigenetics is the study of heritable changes in genome function that occur because of chemical changes rather than DNA sequence changes. DNA methylation is an epigenetic event that results in the silencing of gene expression and may be passed on to the next generation. However, recent studies investigating different physiological states and changes in milk protein gene expression suggest that DNA methylation may also play an acute, regulatory, role in gene transcription. This overview will highlight the role of DNA methylation in the silencing of milk protein gene expression during mastitis and mammary involution. Moreover, environmental factors such as nutrition may induce epigenetic modifications of gene expression. The current research investigating the possibility of in utero, hence cross-generational, epigenetic modifications in dairy cows will also be discussed. Understanding how the mammary gland responds to environmental cues provides a potential to enhance milk production not only of the dairy cow but also of her daughter. |
| first_indexed | 2024-12-14T15:44:54Z |
| format | Article |
| id | doaj.art-dce8def866c44838832e49d1b4771b6b |
| institution | Directory Open Access Journal |
| issn | 1751-7311 |
| language | English |
| last_indexed | 2024-12-14T15:44:54Z |
| publishDate | 2012-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Animal |
| spelling | doaj.art-dce8def866c44838832e49d1b4771b6b2022-12-21T22:55:31ZengElsevierAnimal1751-73112012-01-0163375381Epigenetics: a possible role in acute and transgenerational regulation of dairy cow milk productionK. Singh0A.J. Molenaar1K.M. Swanson2B. Gudex3J.A. Arias4R.A. Erdman5K. Stelwagen6Growth and Lactation Team, Animal Productivity Group, AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New ZealandGrowth and Lactation Team, Animal Productivity Group, AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New ZealandGrowth and Lactation Team, Animal Productivity Group, AgResearch Ltd, Ruakura Research Centre, Private Bag 3123, Hamilton 3240, New ZealandLivestock Improvement Corporation, Hamilton, New ZealandLivestock Improvement Corporation, Hamilton, New ZealandDepartment of Animal and Avian Sciences, University of Maryland, College Park, MD 20742, USASciLactis Ltd, Waikato Innovation Park, Ruakura Road, Hamilton 3240, New ZealandA potential role for epigenetic mechanisms in the regulation of mammary function in the dairy cow is emerging. Epigenetics is the study of heritable changes in genome function that occur because of chemical changes rather than DNA sequence changes. DNA methylation is an epigenetic event that results in the silencing of gene expression and may be passed on to the next generation. However, recent studies investigating different physiological states and changes in milk protein gene expression suggest that DNA methylation may also play an acute, regulatory, role in gene transcription. This overview will highlight the role of DNA methylation in the silencing of milk protein gene expression during mastitis and mammary involution. Moreover, environmental factors such as nutrition may induce epigenetic modifications of gene expression. The current research investigating the possibility of in utero, hence cross-generational, epigenetic modifications in dairy cows will also be discussed. Understanding how the mammary gland responds to environmental cues provides a potential to enhance milk production not only of the dairy cow but also of her daughter.http://www.sciencedirect.com/science/article/pii/S1751731111002564epigeneticsDNA methylationtransgenerationmilk productiondairy cows |
| spellingShingle | K. Singh A.J. Molenaar K.M. Swanson B. Gudex J.A. Arias R.A. Erdman K. Stelwagen Epigenetics: a possible role in acute and transgenerational regulation of dairy cow milk production Animal epigenetics DNA methylation transgeneration milk production dairy cows |
| title | Epigenetics: a possible role in acute and transgenerational regulation of dairy cow milk production |
| title_full | Epigenetics: a possible role in acute and transgenerational regulation of dairy cow milk production |
| title_fullStr | Epigenetics: a possible role in acute and transgenerational regulation of dairy cow milk production |
| title_full_unstemmed | Epigenetics: a possible role in acute and transgenerational regulation of dairy cow milk production |
| title_short | Epigenetics: a possible role in acute and transgenerational regulation of dairy cow milk production |
| title_sort | epigenetics a possible role in acute and transgenerational regulation of dairy cow milk production |
| topic | epigenetics DNA methylation transgeneration milk production dairy cows |
| url | http://www.sciencedirect.com/science/article/pii/S1751731111002564 |
| work_keys_str_mv | AT ksingh epigeneticsapossibleroleinacuteandtransgenerationalregulationofdairycowmilkproduction AT ajmolenaar epigeneticsapossibleroleinacuteandtransgenerationalregulationofdairycowmilkproduction AT kmswanson epigeneticsapossibleroleinacuteandtransgenerationalregulationofdairycowmilkproduction AT bgudex epigeneticsapossibleroleinacuteandtransgenerationalregulationofdairycowmilkproduction AT jaarias epigeneticsapossibleroleinacuteandtransgenerationalregulationofdairycowmilkproduction AT raerdman epigeneticsapossibleroleinacuteandtransgenerationalregulationofdairycowmilkproduction AT kstelwagen epigeneticsapossibleroleinacuteandtransgenerationalregulationofdairycowmilkproduction |