Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation
A manganese (II) complex templated by hexahydro-1,4-diazepinediium as a counter ion was grown by slow evaporation from an aqueous solution at room temperature. The X-ray diffraction analysis revealed that the compound (C<sub>5</sub>H<sub>14</sub>N<sub>2</sub>)[MnC...
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| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Inorganics |
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| Online Access: | https://www.mdpi.com/2304-6740/11/2/76 |
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| author | Mansoura Bourwina Sandra Walha Najeh Krayem Riadh Badraoui Faten Brahmi Wejdan M. Alshammari Mejdi Snoussi Mark M. Turnbull Thierry Roisnel Houcine Naïli |
| author_facet | Mansoura Bourwina Sandra Walha Najeh Krayem Riadh Badraoui Faten Brahmi Wejdan M. Alshammari Mejdi Snoussi Mark M. Turnbull Thierry Roisnel Houcine Naïli |
| author_sort | Mansoura Bourwina |
| collection | DOAJ |
| description | A manganese (II) complex templated by hexahydro-1,4-diazepinediium as a counter ion was grown by slow evaporation from an aqueous solution at room temperature. The X-ray diffraction analysis revealed that the compound (C<sub>5</sub>H<sub>14</sub>N<sub>2</sub>)[MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>] crystallizes in the centrosymmetric space group P2/c of the monoclinic system. The crystal structure of the Mn(II) complex is characterized by an alternation of 0-dimensional organic and inorganic stacks linked together by N/O-H…Cl and N-H…O hydrogen bonds, which lead to a three-dimensional supramolecular architecture. In this structure, the inorganic layer is built up by independent anionic moieties combining the two isomers cis/trans of [MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]<sup>2−</sup>. The thermal decomposition was studied by TGA-DTA techniques. The optical band gap and Urbach energy were obtained by Tauc’s equation. The direct and indirect band gap values are found to be 4.58 and 4.44 eV, respectively. Weak antiferromagnetic interactions are present in the molecule under study, according to magnetic measurements. An agar well diffusion technique was used to assess the synthetic compound’s biological activity, and the results showed that it has potent antibacterial (Gram-positive and Gram-negative) properties. Interestingly, the synthesized compound also displayed antilipase activity. These biological activities have been confirmed by the bioavailability and pharmacokinetic analyses. |
| first_indexed | 2024-03-11T08:40:12Z |
| format | Article |
| id | doaj.art-dce95e944f6c445bb3db9c1a60a61512 |
| institution | Directory Open Access Journal |
| issn | 2304-6740 |
| language | English |
| last_indexed | 2024-03-11T08:40:12Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Inorganics |
| spelling | doaj.art-dce95e944f6c445bb3db9c1a60a615122023-11-16T21:13:36ZengMDPI AGInorganics2304-67402023-02-011127610.3390/inorganics11020076Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological EvaluationMansoura Bourwina0Sandra Walha1Najeh Krayem2Riadh Badraoui3Faten Brahmi4Wejdan M. Alshammari5Mejdi Snoussi6Mark M. Turnbull7Thierry Roisnel8Houcine Naïli9Laboratoire Physico-Chimie de l’Etat Solide, Département de Chimie, Faculté des Sciences de Sfax, Université de Sfax, B.P. 1171, Sfax 3000, TunisiaLaboratoire Physico-Chimie de l’Etat Solide, Département de Chimie, Faculté des Sciences de Sfax, Université de Sfax, B.P. 1171, Sfax 3000, TunisiaLaboratory of Biochemistry and Engineering of Lipases, National School of Engineering of Sfax (ENIS), University of Sfax, Sfax 3000, TunisiaLaboratory of General Biology, Department of Biology, University of Ha’il, Ha’il 81451, Saudi ArabiaLaboratory of Organic Chemistry, Department of Chemistry, University of Ha’il, Ha’il 81451, Saudi ArabiaLaboratory of General Biology, Department of Biology, University of Ha’il, Ha’il 81451, Saudi ArabiaLaboratory of General Biology, Department of Biology, University of Ha’il, Ha’il 81451, Saudi ArabiaCarlson School of Chemistry and Biochemistry, Clark University, Worcester, MA 01610, USAInstitut des Sciences Chimiques de Rennes, UMR 6226 CNRS, Campus de Beaulieu France, Université Rennes, F-35000 Rennes, FranceLaboratoire Physico-Chimie de l’Etat Solide, Département de Chimie, Faculté des Sciences de Sfax, Université de Sfax, B.P. 1171, Sfax 3000, TunisiaA manganese (II) complex templated by hexahydro-1,4-diazepinediium as a counter ion was grown by slow evaporation from an aqueous solution at room temperature. The X-ray diffraction analysis revealed that the compound (C<sub>5</sub>H<sub>14</sub>N<sub>2</sub>)[MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>] crystallizes in the centrosymmetric space group P2/c of the monoclinic system. The crystal structure of the Mn(II) complex is characterized by an alternation of 0-dimensional organic and inorganic stacks linked together by N/O-H…Cl and N-H…O hydrogen bonds, which lead to a three-dimensional supramolecular architecture. In this structure, the inorganic layer is built up by independent anionic moieties combining the two isomers cis/trans of [MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]<sup>2−</sup>. The thermal decomposition was studied by TGA-DTA techniques. The optical band gap and Urbach energy were obtained by Tauc’s equation. The direct and indirect band gap values are found to be 4.58 and 4.44 eV, respectively. Weak antiferromagnetic interactions are present in the molecule under study, according to magnetic measurements. An agar well diffusion technique was used to assess the synthetic compound’s biological activity, and the results showed that it has potent antibacterial (Gram-positive and Gram-negative) properties. Interestingly, the synthesized compound also displayed antilipase activity. These biological activities have been confirmed by the bioavailability and pharmacokinetic analyses.https://www.mdpi.com/2304-6740/11/2/76manganese (II) complexthermal analysisinfrared spectroscopyoptical band gapmagnetic propertiespharmacokinetics |
| spellingShingle | Mansoura Bourwina Sandra Walha Najeh Krayem Riadh Badraoui Faten Brahmi Wejdan M. Alshammari Mejdi Snoussi Mark M. Turnbull Thierry Roisnel Houcine Naïli Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation Inorganics manganese (II) complex thermal analysis infrared spectroscopy optical band gap magnetic properties pharmacokinetics |
| title | Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation |
| title_full | Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation |
| title_fullStr | Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation |
| title_full_unstemmed | Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation |
| title_short | Organic–Inorganic Manganese (II) Halide Hybrid Combining the Two Isomers Cis/Trans of [MnCl<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub>]: Crystal Structure, Physical Properties, Pharmacokinetics and Biological Evaluation |
| title_sort | organic inorganic manganese ii halide hybrid combining the two isomers cis trans of mncl sub 4 sub h sub 2 sub o sub 2 sub crystal structure physical properties pharmacokinetics and biological evaluation |
| topic | manganese (II) complex thermal analysis infrared spectroscopy optical band gap magnetic properties pharmacokinetics |
| url | https://www.mdpi.com/2304-6740/11/2/76 |
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