THE LYMPH SELF ANTIGEN REPERTOIRE
The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the omic composition of the tissue from which it originates in its physiological or pathological signature. Several recent proteomic analyses have mapped the proteome-degradome and peptidome...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-12-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00424/full |
| _version_ | 1819067659964121088 |
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| author | Laura eSantambrogio Cristina eClement |
| author_facet | Laura eSantambrogio Cristina eClement |
| author_sort | Laura eSantambrogio |
| collection | DOAJ |
| description | The lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the omic composition of the tissue from which it originates in its physiological or pathological signature. Several recent proteomic analyses have mapped the proteome-degradome and peptidome of this immunologically relevant fluid pointing to the lymph as an important source of tissue-derived self-antigens. A vast array of lymph-circulating peptides have been mapped deriving from a variety of processing pathways including caspases, cathepsins, MMPs, ADAMs, kallikreins, calpains and granzymes, among others. These self peptides can be directly loaded on circulatory dendritic cells and expand the self-antigenic repertoire available for central and peripheral tolerance. |
| first_indexed | 2024-12-21T16:21:47Z |
| format | Article |
| id | doaj.art-dcebd2345b4d40bc9929e34c77cb4cc8 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-21T16:21:47Z |
| publishDate | 2013-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-dcebd2345b4d40bc9929e34c77cb4cc82022-12-21T18:57:34ZengFrontiers Media S.A.Frontiers in Immunology1664-32242013-12-01410.3389/fimmu.2013.0042467598THE LYMPH SELF ANTIGEN REPERTOIRELaura eSantambrogio0Cristina eClement1Albert Einstein College of MedicineAlbert Einstein College of MedicineThe lymphatic fluid originates from the interstitial fluid which bathes every parenchymal organ and reflects the omic composition of the tissue from which it originates in its physiological or pathological signature. Several recent proteomic analyses have mapped the proteome-degradome and peptidome of this immunologically relevant fluid pointing to the lymph as an important source of tissue-derived self-antigens. A vast array of lymph-circulating peptides have been mapped deriving from a variety of processing pathways including caspases, cathepsins, MMPs, ADAMs, kallikreins, calpains and granzymes, among others. These self peptides can be directly loaded on circulatory dendritic cells and expand the self-antigenic repertoire available for central and peripheral tolerance.http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00424/fullAntigen PresentationLymphPeptidesantigen processingMHC class II |
| spellingShingle | Laura eSantambrogio Cristina eClement THE LYMPH SELF ANTIGEN REPERTOIRE Frontiers in Immunology Antigen Presentation Lymph Peptides antigen processing MHC class II |
| title | THE LYMPH SELF ANTIGEN REPERTOIRE |
| title_full | THE LYMPH SELF ANTIGEN REPERTOIRE |
| title_fullStr | THE LYMPH SELF ANTIGEN REPERTOIRE |
| title_full_unstemmed | THE LYMPH SELF ANTIGEN REPERTOIRE |
| title_short | THE LYMPH SELF ANTIGEN REPERTOIRE |
| title_sort | lymph self antigen repertoire |
| topic | Antigen Presentation Lymph Peptides antigen processing MHC class II |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00424/full |
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