Oceans as a Source of Immunotherapy
Marine flora is taxonomically diverse, biologically active, and chemically unique. It is an excellent resource, which offers great opportunities for the discovery of new biopharmaceuticals such as immunomodulators and drugs targeting cancerous, inflammatory, microbial, and fungal diseases. The abili...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019-05-01
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| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/17/5/282 |
| _version_ | 1818037206983376896 |
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| author | Bilal Ahmad Masaud Shah Sangdun Choi |
| author_facet | Bilal Ahmad Masaud Shah Sangdun Choi |
| author_sort | Bilal Ahmad |
| collection | DOAJ |
| description | Marine flora is taxonomically diverse, biologically active, and chemically unique. It is an excellent resource, which offers great opportunities for the discovery of new biopharmaceuticals such as immunomodulators and drugs targeting cancerous, inflammatory, microbial, and fungal diseases. The ability of some marine molecules to mediate specific inhibitory activities has been demonstrated in a range of cellular processes, including apoptosis, angiogenesis, and cell migration and adhesion. Immunomodulators have been shown to have significant therapeutic effects on immune-mediated diseases, but the search for safe and effective immunotherapies for other diseases such as sinusitis, atopic dermatitis, rheumatoid arthritis, asthma and allergies is ongoing. This review focuses on the marine-originated bioactive molecules with immunomodulatory potential, with a particular focus on the molecular mechanisms of specific agents with respect to their targets. It also addresses the commercial utilization of these compounds for possible drug improvement using metabolic engineering and genomics. |
| first_indexed | 2024-12-10T07:23:10Z |
| format | Article |
| id | doaj.art-dcef7031bbfa44dc8f82e289c9c31fc5 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-12-10T07:23:10Z |
| publishDate | 2019-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-dcef7031bbfa44dc8f82e289c9c31fc52022-12-22T01:57:45ZengMDPI AGMarine Drugs1660-33972019-05-0117528210.3390/md17050282md17050282Oceans as a Source of ImmunotherapyBilal Ahmad0Masaud Shah1Sangdun Choi2Department of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaDepartment of Molecular Science and Technology, Ajou University, Suwon 16499, KoreaMarine flora is taxonomically diverse, biologically active, and chemically unique. It is an excellent resource, which offers great opportunities for the discovery of new biopharmaceuticals such as immunomodulators and drugs targeting cancerous, inflammatory, microbial, and fungal diseases. The ability of some marine molecules to mediate specific inhibitory activities has been demonstrated in a range of cellular processes, including apoptosis, angiogenesis, and cell migration and adhesion. Immunomodulators have been shown to have significant therapeutic effects on immune-mediated diseases, but the search for safe and effective immunotherapies for other diseases such as sinusitis, atopic dermatitis, rheumatoid arthritis, asthma and allergies is ongoing. This review focuses on the marine-originated bioactive molecules with immunomodulatory potential, with a particular focus on the molecular mechanisms of specific agents with respect to their targets. It also addresses the commercial utilization of these compounds for possible drug improvement using metabolic engineering and genomics.https://www.mdpi.com/1660-3397/17/5/282immunotherapyinflammationmarine drugmarine floraToll-like receptor |
| spellingShingle | Bilal Ahmad Masaud Shah Sangdun Choi Oceans as a Source of Immunotherapy Marine Drugs immunotherapy inflammation marine drug marine flora Toll-like receptor |
| title | Oceans as a Source of Immunotherapy |
| title_full | Oceans as a Source of Immunotherapy |
| title_fullStr | Oceans as a Source of Immunotherapy |
| title_full_unstemmed | Oceans as a Source of Immunotherapy |
| title_short | Oceans as a Source of Immunotherapy |
| title_sort | oceans as a source of immunotherapy |
| topic | immunotherapy inflammation marine drug marine flora Toll-like receptor |
| url | https://www.mdpi.com/1660-3397/17/5/282 |
| work_keys_str_mv | AT bilalahmad oceansasasourceofimmunotherapy AT masaudshah oceansasasourceofimmunotherapy AT sangdunchoi oceansasasourceofimmunotherapy |