Solid-phase Synthesis of Tetrapeptide on 2-Chlorotrityl Chloride Resin by Using Benzotriazol-1-yl-oxytripyrrolidinophosphonium Hexafluorophosphate as Coupling Reagent

Solid-phase Synthesis of Tetrapeptide on 2-Chlorotrityl Chloride Resin by Using Benzotriazol-1-yl-oxytripyrrolidinophosphonium Hexafluorophosphate as Coupling Reagent

Tetrapeptide, OH-Pro-Ala-Gly-Tyr-NH2, was successfully synthesised on 2-chlorotrityl chloride resin by taking advantage of PyBOP (benzotriazol-1-yl-oxytripyrrolidinophosphonium hexafluorophosphate) as coupling reagent. The selection of the peptide as the target of synthesis was due to its interestin...

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Bibliographic Details
Main Authors: Rani Maharani, Nuruzzahra Ammatillah, Gunawan Gunawan, Ace Tatang Hidayat
Format: Article
Language:Indonesian
Published: Syarif Hidayatullah Jakarta State Islamic University 2016-12-01
Series:Jurnal Kimia Valensi
Subjects:
solid-phase peptide synthesis
tetrapeptide
2-chlorotrityl chloride
pybop
fmoc strategy
Online Access:http://journal.uinjkt.ac.id/index.php/valensi/article/view/4055

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