Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy
In this study, we aimed to investigate the concept of pseudoprogression in colorectal cancer patients with liver metastases receiving bevacizumab treatment by considering the changes in the shape, size, and density of liver metastases by abdominal Computed Tomography (CT) scans taken before and afte...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2023-09-01
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| Series: | Medicine Science |
| Subjects: | |
| Online Access: | https://www.medicinescience.org/?mno=156387 |
| _version_ | 1797316553397501952 |
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| author | Pinar Ozdemir Akdur Nazan Ciledag Burcu Savran Ayse Ocak Duran |
| author_facet | Pinar Ozdemir Akdur Nazan Ciledag Burcu Savran Ayse Ocak Duran |
| author_sort | Pinar Ozdemir Akdur |
| collection | DOAJ |
| description | In this study, we aimed to investigate the concept of pseudoprogression in colorectal cancer patients with liver metastases receiving bevacizumab treatment by considering the changes in the shape, size, and density of liver metastases by abdominal Computed Tomography (CT) scans taken before and after treatment. This study is a retrospective evaluation of 16 patients with metastatic colorectal cancer treated with 5-fluorouracil, leucovorin, irinotecan and bevacizumab and is based on computed tissue analysis of the dominant liver lesion at baseline and 2 months after chemotherapy. The borders of all metastatic lesions observed in the livers of patients treated with bevacizumab after adjuvant chemotherapy were sharpened, the size of some lesions remained the same while others increased, and the density of most metastatic lesions decreased. In our study, we concluded that the evaluation of response to treatment based only on size and number should be avoided by noting a pseudoprogression in liver metastases that shows an increase in size but no progression on clinical/laboratory and follow-up images. [Med-Science 2023; 12(3.000): 951-4] |
| first_indexed | 2024-03-08T03:20:06Z |
| format | Article |
| id | doaj.art-dcf0d7f874d74f6dbb800f4b62c356b4 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T03:20:06Z |
| publishDate | 2023-09-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-dcf0d7f874d74f6dbb800f4b62c356b42024-02-12T10:33:06ZengSociety of Turaz BilimMedicine Science2147-06342023-09-01123951410.5455/medscience.2023.06.084156387Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapyPinar Ozdemir Akdur0Nazan Ciledag1Burcu Savran2Ayse Ocak Duran3SBU Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital SBU Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital SBU Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital SBU Dr. Abdurrahman Yurtaslan Oncology Training and Research HospitalIn this study, we aimed to investigate the concept of pseudoprogression in colorectal cancer patients with liver metastases receiving bevacizumab treatment by considering the changes in the shape, size, and density of liver metastases by abdominal Computed Tomography (CT) scans taken before and after treatment. This study is a retrospective evaluation of 16 patients with metastatic colorectal cancer treated with 5-fluorouracil, leucovorin, irinotecan and bevacizumab and is based on computed tissue analysis of the dominant liver lesion at baseline and 2 months after chemotherapy. The borders of all metastatic lesions observed in the livers of patients treated with bevacizumab after adjuvant chemotherapy were sharpened, the size of some lesions remained the same while others increased, and the density of most metastatic lesions decreased. In our study, we concluded that the evaluation of response to treatment based only on size and number should be avoided by noting a pseudoprogression in liver metastases that shows an increase in size but no progression on clinical/laboratory and follow-up images. [Med-Science 2023; 12(3.000): 951-4]https://www.medicinescience.org/?mno=156387bevacizumabcolon cancerpseudoprogressionmetastasis |
| spellingShingle | Pinar Ozdemir Akdur Nazan Ciledag Burcu Savran Ayse Ocak Duran Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy Medicine Science bevacizumab colon cancer pseudoprogression metastasis |
| title | Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy |
| title_full | Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy |
| title_fullStr | Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy |
| title_full_unstemmed | Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy |
| title_short | Pseudoprogression; discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy |
| title_sort | pseudoprogression discussion of the concept of pseudoprogression on the characteristics of tomographic changes in liver metastases of colorectal cancer patients receiving bevacizumab therapy |
| topic | bevacizumab colon cancer pseudoprogression metastasis |
| url | https://www.medicinescience.org/?mno=156387 |
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