The role of red cell distribution width in the locoregional recurrence of laryngeal cancer
Introduction: Although the red cell distribution width has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge few reports have focused on the prognostic value of red cell distribution width in laryngeal carcinoma. Objective: We aimed to explore whether th...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-05-01
|
| Series: | Brazilian Journal of Otorhinolaryngology |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1808869418300934 |
| _version_ | 1818642413652017152 |
|---|---|
| author | Gülpembe Bozkurt Arzu Yasemin Korkut Pınar Soytaş Senem Kurt Dizdar Zeynep Nur Erol |
| author_facet | Gülpembe Bozkurt Arzu Yasemin Korkut Pınar Soytaş Senem Kurt Dizdar Zeynep Nur Erol |
| author_sort | Gülpembe Bozkurt |
| collection | DOAJ |
| description | Introduction: Although the red cell distribution width has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge few reports have focused on the prognostic value of red cell distribution width in laryngeal carcinoma. Objective: We aimed to explore whether the pretreatment red cell distribution width predicted recurrence in laryngeal cancer patients is a simple, reproducible, and inexpensive prognostic biomarker. Methods: All laryngeal cancer patients who underwent curative surgery (n = 132) over a 7 year study period were evaluated. Data on demographics, primary tumor site, T-stage, N-stage, histological features (differentiation; the presence of perineural/perivascular invasion), treatment group (total laryngectomy or partial laryngectomy) or adjuvant therapy (chemotherapy/radiotherapy); laboratory parameters (complete blood count, including the pre-operative red cell distribution width), and disease-free survival rates were retrospectively reviewed. All cases were divided into three groups by the red cell distribution width tertile [<13% (25th percentile) (n = 31), 13–14.4% (50th percentile) (n = 72), and >14.4% (75th percentile) (n = 29)]. Results: High-red cell distribution width group included more patients of advanced age, and more of those with recurrent and metastatic tumors (p = 0.005, 0.048, and 0.043, respectively). Individuals with red cell distribution width >14.4% (75th percentile) had lower disease free survival rates than did those with red cell distribution width <13% (25th percentile) (p = 0.014). Patients with red cell distribution width >14.4% at diagnosis were at a higher risk of locoregional recurrence (hazard ratio = 5.818, 95% confidence interval (95% CI) 1.25–26.97; p = 0.024) than patients with a normal red cell distribution width (<13%). Conclusion: We found that the pretreatment red cell distribution width was independently prognostic of disease free survival rate in patients with laryngeal cancer and may serve as a new, accurate, and reproducible means of identifying early-stage laryngeal cancer patients with poorer prognoses. Resumo: Introdução: Embora a amplitude de distribuição de eritrócitos tenha sido relatada como um preditor confiável de prognóstico em vários tipos de câncer, que seja de nosso conhecimento, poucos estudos se concentraram no valor prognóstico dessa medida no carcinoma laríngeo. Objetivo: Avaliar se a amplitude de distribuição de eritrócitos pré-tratamento prevê a recorrência em pacientes com câncer de laringe como um biomarcador prognóstico simples, reprodutível e não dispendioso. Método: Foram avaliados todos os pacientes com câncer de laringe submetidos à cirurgia curativa (n = 132) durante sete anos. Dados demográficos, local do tumor primário, estágio T, estágio N, características histológicas (diferenciação; presença de invasão perineural/perivascular), grupo de tratamento (laringectomia total ou laringectomia parcial) ou terapia adjuvante (quimioterapia/radioterapia); parâmetros laboratoriais (hemograma, inclusive a amplitude de distribuição de eritrócitos pré-operatório) e a sobrevida livre de doença foram revisados retrospectivamente. Todos os casos foram divididos em três grupos pelo tercil da amplitude de distribuição de eritrócitos [< 13% (percentil 25) (n = 31), 13% – 14,4% (percentil 50) (n = 72) e > 14,4% (percentil 75) (n = 29)]. Resultados: O grupo com amplitude de distribuição de eritrócitos elevado incluiu um número maior de pacientes com idade avançada e mais pacientes com tumores recorrentes e metastáticos (p = 0,005, 0,048 e 0,043, respectivamente). Os indivíduos com a amplitude de distribuição de eritrócitos >14,4% (percentil 75) apresentaram taxas de sobrevida livre de doença menores do que aqueles com a amplitude de distribuição de eritrócitos <13% (percentil 25) (p = 0,014). Pacientes com a amplitude de distribuição de eritrócitos >14,4% no diagnóstico apresentaram maior risco de recorrência locorregional [Hazard Ratio = 5,818, intervalo de confiança de 95% (IC 95%) 1,25–26,97; p = 0,024] do que pacientes com a amplitude de distribuição de eritrócitos normal (< 13%). Conclusão: Verificamos que a amplitude de distribuição de eritrócitos pré-tratamento foi um fator prognóstico independente de sobrevida livre de doença em pacientes com câncer de laringe e pode servir como um novo parâmetro, preciso e reprodutível, para identificar pacientes com câncer de laringe em estágio inicial com piores prognósticos. Keywords: Red cell distribution width, Larynx cancer, Disease free survival, Palavras-chave: Amplitude de distribuição de eritrócitos, Câncer de laringe, Sobrevida livre de doença |
| first_indexed | 2024-12-16T23:42:40Z |
| format | Article |
| id | doaj.art-dcf11a5e0b1f4bae829d38dfb1db61d9 |
| institution | Directory Open Access Journal |
| issn | 1808-8694 |
| language | English |
| last_indexed | 2024-12-16T23:42:40Z |
| publishDate | 2019-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Otorhinolaryngology |
| spelling | doaj.art-dcf11a5e0b1f4bae829d38dfb1db61d92022-12-21T22:11:34ZengElsevierBrazilian Journal of Otorhinolaryngology1808-86942019-05-01853357364The role of red cell distribution width in the locoregional recurrence of laryngeal cancerGülpembe Bozkurt0Arzu Yasemin Korkut1Pınar Soytaş2Senem Kurt Dizdar3Zeynep Nur Erol4Acibadem University, School of Medicine, Department of Otolaryngology, Head and Neck Surgery, Istanbul, Turkey; Corresponding author.Sisli Hamidiye Etfal Education and Research Hospital, Department of Otolaryngology, Istanbul, TurkeySisli Hamidiye Etfal Education and Research Hospital, Department of Otolaryngology, Istanbul, TurkeySisli Hamidiye Etfal Education and Research Hospital, Department of Otolaryngology, Istanbul, TurkeyHopa State Hospital, Department of Otolaryngology, Artvin, TurkeyIntroduction: Although the red cell distribution width has been reported as a reliable predictor of prognosis in several types of cancer, to our knowledge few reports have focused on the prognostic value of red cell distribution width in laryngeal carcinoma. Objective: We aimed to explore whether the pretreatment red cell distribution width predicted recurrence in laryngeal cancer patients is a simple, reproducible, and inexpensive prognostic biomarker. Methods: All laryngeal cancer patients who underwent curative surgery (n = 132) over a 7 year study period were evaluated. Data on demographics, primary tumor site, T-stage, N-stage, histological features (differentiation; the presence of perineural/perivascular invasion), treatment group (total laryngectomy or partial laryngectomy) or adjuvant therapy (chemotherapy/radiotherapy); laboratory parameters (complete blood count, including the pre-operative red cell distribution width), and disease-free survival rates were retrospectively reviewed. All cases were divided into three groups by the red cell distribution width tertile [<13% (25th percentile) (n = 31), 13–14.4% (50th percentile) (n = 72), and >14.4% (75th percentile) (n = 29)]. Results: High-red cell distribution width group included more patients of advanced age, and more of those with recurrent and metastatic tumors (p = 0.005, 0.048, and 0.043, respectively). Individuals with red cell distribution width >14.4% (75th percentile) had lower disease free survival rates than did those with red cell distribution width <13% (25th percentile) (p = 0.014). Patients with red cell distribution width >14.4% at diagnosis were at a higher risk of locoregional recurrence (hazard ratio = 5.818, 95% confidence interval (95% CI) 1.25–26.97; p = 0.024) than patients with a normal red cell distribution width (<13%). Conclusion: We found that the pretreatment red cell distribution width was independently prognostic of disease free survival rate in patients with laryngeal cancer and may serve as a new, accurate, and reproducible means of identifying early-stage laryngeal cancer patients with poorer prognoses. Resumo: Introdução: Embora a amplitude de distribuição de eritrócitos tenha sido relatada como um preditor confiável de prognóstico em vários tipos de câncer, que seja de nosso conhecimento, poucos estudos se concentraram no valor prognóstico dessa medida no carcinoma laríngeo. Objetivo: Avaliar se a amplitude de distribuição de eritrócitos pré-tratamento prevê a recorrência em pacientes com câncer de laringe como um biomarcador prognóstico simples, reprodutível e não dispendioso. Método: Foram avaliados todos os pacientes com câncer de laringe submetidos à cirurgia curativa (n = 132) durante sete anos. Dados demográficos, local do tumor primário, estágio T, estágio N, características histológicas (diferenciação; presença de invasão perineural/perivascular), grupo de tratamento (laringectomia total ou laringectomia parcial) ou terapia adjuvante (quimioterapia/radioterapia); parâmetros laboratoriais (hemograma, inclusive a amplitude de distribuição de eritrócitos pré-operatório) e a sobrevida livre de doença foram revisados retrospectivamente. Todos os casos foram divididos em três grupos pelo tercil da amplitude de distribuição de eritrócitos [< 13% (percentil 25) (n = 31), 13% – 14,4% (percentil 50) (n = 72) e > 14,4% (percentil 75) (n = 29)]. Resultados: O grupo com amplitude de distribuição de eritrócitos elevado incluiu um número maior de pacientes com idade avançada e mais pacientes com tumores recorrentes e metastáticos (p = 0,005, 0,048 e 0,043, respectivamente). Os indivíduos com a amplitude de distribuição de eritrócitos >14,4% (percentil 75) apresentaram taxas de sobrevida livre de doença menores do que aqueles com a amplitude de distribuição de eritrócitos <13% (percentil 25) (p = 0,014). Pacientes com a amplitude de distribuição de eritrócitos >14,4% no diagnóstico apresentaram maior risco de recorrência locorregional [Hazard Ratio = 5,818, intervalo de confiança de 95% (IC 95%) 1,25–26,97; p = 0,024] do que pacientes com a amplitude de distribuição de eritrócitos normal (< 13%). Conclusão: Verificamos que a amplitude de distribuição de eritrócitos pré-tratamento foi um fator prognóstico independente de sobrevida livre de doença em pacientes com câncer de laringe e pode servir como um novo parâmetro, preciso e reprodutível, para identificar pacientes com câncer de laringe em estágio inicial com piores prognósticos. Keywords: Red cell distribution width, Larynx cancer, Disease free survival, Palavras-chave: Amplitude de distribuição de eritrócitos, Câncer de laringe, Sobrevida livre de doençahttp://www.sciencedirect.com/science/article/pii/S1808869418300934 |
| spellingShingle | Gülpembe Bozkurt Arzu Yasemin Korkut Pınar Soytaş Senem Kurt Dizdar Zeynep Nur Erol The role of red cell distribution width in the locoregional recurrence of laryngeal cancer Brazilian Journal of Otorhinolaryngology |
| title | The role of red cell distribution width in the locoregional recurrence of laryngeal cancer |
| title_full | The role of red cell distribution width in the locoregional recurrence of laryngeal cancer |
| title_fullStr | The role of red cell distribution width in the locoregional recurrence of laryngeal cancer |
| title_full_unstemmed | The role of red cell distribution width in the locoregional recurrence of laryngeal cancer |
| title_short | The role of red cell distribution width in the locoregional recurrence of laryngeal cancer |
| title_sort | role of red cell distribution width in the locoregional recurrence of laryngeal cancer |
| url | http://www.sciencedirect.com/science/article/pii/S1808869418300934 |
| work_keys_str_mv | AT gulpembebozkurt theroleofredcelldistributionwidthinthelocoregionalrecurrenceoflaryngealcancer AT arzuyaseminkorkut theroleofredcelldistributionwidthinthelocoregionalrecurrenceoflaryngealcancer AT pınarsoytas theroleofredcelldistributionwidthinthelocoregionalrecurrenceoflaryngealcancer AT senemkurtdizdar theroleofredcelldistributionwidthinthelocoregionalrecurrenceoflaryngealcancer AT zeynepnurerol theroleofredcelldistributionwidthinthelocoregionalrecurrenceoflaryngealcancer AT gulpembebozkurt roleofredcelldistributionwidthinthelocoregionalrecurrenceoflaryngealcancer AT arzuyaseminkorkut roleofredcelldistributionwidthinthelocoregionalrecurrenceoflaryngealcancer AT pınarsoytas roleofredcelldistributionwidthinthelocoregionalrecurrenceoflaryngealcancer AT senemkurtdizdar roleofredcelldistributionwidthinthelocoregionalrecurrenceoflaryngealcancer AT zeynepnurerol roleofredcelldistributionwidthinthelocoregionalrecurrenceoflaryngealcancer |