Occult Hepatitis B Virus Infection in Chacma Baboons, South Africa
During previous studies of susceptibility to hepatitis B virus (HBV) infection, HBV DNA was detected in 2/6 wild-caught baboons. In the present study, HBV DNA was amplified from 15/69 wild-caught baboons. All animals were negative for HBV surface antigen and antibody against HBV core antigen. Liver...
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2013-04-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/19/4/12-1107_article |
| _version_ | 1818408679108509696 |
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| author | Caroline Dickens Michael C. Kew Robert H. Purcell Anna Kramvis |
| author_facet | Caroline Dickens Michael C. Kew Robert H. Purcell Anna Kramvis |
| author_sort | Caroline Dickens |
| collection | DOAJ |
| description | During previous studies of susceptibility to hepatitis B virus (HBV) infection, HBV DNA was detected in 2/6 wild-caught baboons. In the present study, HBV DNA was amplified from 15/69 wild-caught baboons. All animals were negative for HBV surface antigen and antibody against HBV core antigen. Liver tissue from 1 baboon was immunohistochemically negative for HBV surface antigen but positive for HBV core antigen. The complete HBV genome of an isolate from this liver clustered with subgenotype A2. Reverse transcription PCR of liver RNA amplified virus precore and surface protein genes, indicating replication of virus in baboon liver tissue. Four experimentally naive baboons were injected with serum from HBV DNA–positive baboons. These 4 baboons showed transient seroconversion, and HBV DNA was amplified from serum at various times after infection. The presence of HBV DNA at relatively low levels and in the absence of serologic markers in the baboon, a nonhuman primate, indicates an occult infection. |
| first_indexed | 2024-12-14T09:47:33Z |
| format | Article |
| id | doaj.art-dcf168d88bb848c9bb38d3d3c06a1371 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-14T09:47:33Z |
| publishDate | 2013-04-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-dcf168d88bb848c9bb38d3d3c06a13712022-12-21T23:07:36ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592013-04-0119459860510.3201/eid1904.121107Occult Hepatitis B Virus Infection in Chacma Baboons, South AfricaCaroline DickensMichael C. KewRobert H. PurcellAnna KramvisDuring previous studies of susceptibility to hepatitis B virus (HBV) infection, HBV DNA was detected in 2/6 wild-caught baboons. In the present study, HBV DNA was amplified from 15/69 wild-caught baboons. All animals were negative for HBV surface antigen and antibody against HBV core antigen. Liver tissue from 1 baboon was immunohistochemically negative for HBV surface antigen but positive for HBV core antigen. The complete HBV genome of an isolate from this liver clustered with subgenotype A2. Reverse transcription PCR of liver RNA amplified virus precore and surface protein genes, indicating replication of virus in baboon liver tissue. Four experimentally naive baboons were injected with serum from HBV DNA–positive baboons. These 4 baboons showed transient seroconversion, and HBV DNA was amplified from serum at various times after infection. The presence of HBV DNA at relatively low levels and in the absence of serologic markers in the baboon, a nonhuman primate, indicates an occult infection.https://wwwnc.cdc.gov/eid/article/19/4/12-1107_articlehepatitis B virusvirusesnonhuman primategenotypestransmissionsilent infection |
| spellingShingle | Caroline Dickens Michael C. Kew Robert H. Purcell Anna Kramvis Occult Hepatitis B Virus Infection in Chacma Baboons, South Africa Emerging Infectious Diseases hepatitis B virus viruses nonhuman primate genotypes transmission silent infection |
| title | Occult Hepatitis B Virus Infection in Chacma Baboons, South Africa |
| title_full | Occult Hepatitis B Virus Infection in Chacma Baboons, South Africa |
| title_fullStr | Occult Hepatitis B Virus Infection in Chacma Baboons, South Africa |
| title_full_unstemmed | Occult Hepatitis B Virus Infection in Chacma Baboons, South Africa |
| title_short | Occult Hepatitis B Virus Infection in Chacma Baboons, South Africa |
| title_sort | occult hepatitis b virus infection in chacma baboons south africa |
| topic | hepatitis B virus viruses nonhuman primate genotypes transmission silent infection |
| url | https://wwwnc.cdc.gov/eid/article/19/4/12-1107_article |
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