Modified influenza M158–66 peptide vaccination induces non-relevant T-cells and may enhance pathology after challenge

Modified influenza M158–66 peptide vaccination induces non-relevant T-cells and may enhance pathology after challenge

Abstract CD8 + T cells are promising targets for vaccination against influenza A virus (IAV) infection. Their induction via peptide vaccination is not trivial, because peptides are weakly immunogenic. One strategy to overcome this is by vaccination with chemically enhanced altered peptide ligands (C...

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Bibliographic Details
Main Authors: Josien Lanfermeijer, Koen van de Ven, Harry van Dijken, Marion Hendriks, Cami M. P. Talavera Ormeño, Femke de Heij, Paul Roholl, José A. M. Borghans, Debbie van Baarle, Jørgen de Jonge
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-023-00705-y

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