A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine
The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alt...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2022-08-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100306&lng=en&tlng=en |
| _version_ | 1811283583431606272 |
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| author | G.M. Gimenes G.O. Santana M.V.M. Scervino R. Curi J.N.B. Pereira |
| author_facet | G.M. Gimenes G.O. Santana M.V.M. Scervino R. Curi J.N.B. Pereira |
| author_sort | G.M. Gimenes |
| collection | DOAJ |
| description | The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state. |
| first_indexed | 2024-04-13T02:14:13Z |
| format | Article |
| id | doaj.art-dcf3e78aa7f1433cb7c8aa3cd0f3d7ce |
| institution | Directory Open Access Journal |
| issn | 1414-431X |
| language | English |
| last_indexed | 2024-04-13T02:14:13Z |
| publishDate | 2022-08-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-dcf3e78aa7f1433cb7c8aa3cd0f3d7ce2022-12-22T03:07:12ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research1414-431X2022-08-015510.1590/1414-431x2022e11910A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestineG.M. Gimeneshttps://orcid.org/0000-0002-3432-1668G.O. Santanahttps://orcid.org/0000-0002-8443-6949M.V.M. Scervinohttps://orcid.org/0000-0002-5742-8820R. Curihttps://orcid.org/0000-0001-5095-9154J.N.B. Pereirahttps://orcid.org/0000-0003-2609-5450The Goto-Kakizaki (GK) rat is a non-obese experimental model of type 2 diabetes mellitus (T2DM) that allows researchers to monitor diabetes-induced changes without jeopardizing the effects of obesity. This rat strain exhibits notable gastrointestinal features associated with T2DM, such as marked alterations in intestinal morphology, reduced intestinal motility, slow transit, and modified microbiota compared to Wistar rats. The primary treatments for diabetic patients include administration of hypoglycemic agents and insulin, and lifestyle changes. Emerging procedures, including alternative therapies, metabolic surgeries, and modulation of the intestinal microbiota composition, have been shown to improve the diabetic state of GK rats. This review describes the morpho-physiological diabetic-associated features of the gastrointestinal tract (GIT) of GK rats. We also describe promising strategies, e.g., metabolic surgery and modulation of gut microbiota composition, used to target the GIT of this animal model to improve the diabetic state.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100306&lng=en&tlng=enGastrointestinal tractType 2 diabetesGK ratsIntestinal microbiotaDiabetes treatment |
| spellingShingle | G.M. Gimenes G.O. Santana M.V.M. Scervino R. Curi J.N.B. Pereira A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine Brazilian Journal of Medical and Biological Research Gastrointestinal tract Type 2 diabetes GK rats Intestinal microbiota Diabetes treatment |
| title | A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine |
| title_full | A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine |
| title_fullStr | A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine |
| title_full_unstemmed | A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine |
| title_short | A short review on the features of the non-obese diabetic Goto-Kakizaki rat intestine |
| title_sort | short review on the features of the non obese diabetic goto kakizaki rat intestine |
| topic | Gastrointestinal tract Type 2 diabetes GK rats Intestinal microbiota Diabetes treatment |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2022000100306&lng=en&tlng=en |
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