Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration
Peripheral nerve injury (PNI) occurs frequently, and the prognosis is unsatisfactory. As the gold standard of treatment, autologous nerve grafting has several disadvantages, such as lack of donors and complications. The use of functional biomaterials to simulate the natural microenvironment of the n...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/8/1/41 |
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| author | Fengshi Zhang Meng Zhang Songyang Liu Ci Li Zhentao Ding Teng Wan Peixun Zhang |
| author_facet | Fengshi Zhang Meng Zhang Songyang Liu Ci Li Zhentao Ding Teng Wan Peixun Zhang |
| author_sort | Fengshi Zhang |
| collection | DOAJ |
| description | Peripheral nerve injury (PNI) occurs frequently, and the prognosis is unsatisfactory. As the gold standard of treatment, autologous nerve grafting has several disadvantages, such as lack of donors and complications. The use of functional biomaterials to simulate the natural microenvironment of the nervous system and the combination of different biomaterials are considered to be encouraging alternative methods for effective tissue regeneration and functional restoration of injured nerves. Considering the inherent presence of an electric field in the nervous system, electrically conductive biomaterials have been used to promote nerve regeneration. Due to their singular physical properties, hydrogels can provide a three-dimensional hydrated network that can be integrated into diverse sizes and shapes and stimulate the natural functions of nerve tissue. Therefore, conductive hydrogels have become the most effective biological material to simulate human nervous tissue’s biological and electrical characteristics. The principal merits of conductive hydrogels include their physical properties and their electrical peculiarities sufficient to effectively transmit electrical signals to cells. This review summarizes the recent applications of conductive hydrogels to enhance peripheral nerve regeneration. |
| first_indexed | 2024-03-10T01:27:14Z |
| format | Article |
| id | doaj.art-dcf4b49ce91f47ac9c89184884093ca5 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-10T01:27:14Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-dcf4b49ce91f47ac9c89184884093ca52023-11-23T13:50:20ZengMDPI AGGels2310-28612022-01-01814110.3390/gels8010041Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve RegenerationFengshi Zhang0Meng Zhang1Songyang Liu2Ci Li3Zhentao Ding4Teng Wan5Peixun Zhang6Department of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100044, ChinaDepartment of Orthopedics and Trauma, Peking University People’s Hospital, Beijing 100044, ChinaPeripheral nerve injury (PNI) occurs frequently, and the prognosis is unsatisfactory. As the gold standard of treatment, autologous nerve grafting has several disadvantages, such as lack of donors and complications. The use of functional biomaterials to simulate the natural microenvironment of the nervous system and the combination of different biomaterials are considered to be encouraging alternative methods for effective tissue regeneration and functional restoration of injured nerves. Considering the inherent presence of an electric field in the nervous system, electrically conductive biomaterials have been used to promote nerve regeneration. Due to their singular physical properties, hydrogels can provide a three-dimensional hydrated network that can be integrated into diverse sizes and shapes and stimulate the natural functions of nerve tissue. Therefore, conductive hydrogels have become the most effective biological material to simulate human nervous tissue’s biological and electrical characteristics. The principal merits of conductive hydrogels include their physical properties and their electrical peculiarities sufficient to effectively transmit electrical signals to cells. This review summarizes the recent applications of conductive hydrogels to enhance peripheral nerve regeneration.https://www.mdpi.com/2310-2861/8/1/41conductive hydrogeltissue engineeringperipheral nerve regenerationcell proliferation |
| spellingShingle | Fengshi Zhang Meng Zhang Songyang Liu Ci Li Zhentao Ding Teng Wan Peixun Zhang Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration Gels conductive hydrogel tissue engineering peripheral nerve regeneration cell proliferation |
| title | Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration |
| title_full | Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration |
| title_fullStr | Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration |
| title_full_unstemmed | Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration |
| title_short | Application of Hybrid Electrically Conductive Hydrogels Promotes Peripheral Nerve Regeneration |
| title_sort | application of hybrid electrically conductive hydrogels promotes peripheral nerve regeneration |
| topic | conductive hydrogel tissue engineering peripheral nerve regeneration cell proliferation |
| url | https://www.mdpi.com/2310-2861/8/1/41 |
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