Integrated CRISPR-Cas9 System-Mediated Knockout of IFN-γ and IFN-γ Receptor 1 in the Vero Cell Line Promotes Viral Susceptibility

Integrated CRISPR-Cas9 System-Mediated Knockout of IFN-γ and IFN-γ Receptor 1 in the Vero Cell Line Promotes Viral Susceptibility

The current pandemic and the possible emergence of new viruses urgently require the rapid development of antiviral vaccines and therapeutics. However, some viruses or newly generated variants are difficult to culture in common cell types or exhibit low viral susceptibility in vivo, making it difficu...

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Bibliographic Details
Main Authors: Suyeon Kim, Aleksandra Nowakowska, Young Bong Kim, Ha Youn Shin
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:International Journal of Molecular Sciences
Subjects:
CRISPR-Cas9
interferon-gamma pathway
knockout
virus susceptibility
Online Access:https://www.mdpi.com/1422-0067/23/15/8217

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