Pseudomonas aeruginosa necrotizing bronchopneumonia

Extremely low birth weight (ELBW) infants are at particularly high risk for infection due to an immature immune system, invasive procedures such as endotracheal intubation, intravascular catheterization, and other factors. Neonatal infections in this population are associated with a high mortality,...

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Main Author: Ranjit I Kylat
Format: Article
Language:English
Published: University of São Paulo 2021-08-01
Series:Autopsy and Case Reports
Subjects:
Online Access:https://www.revistas.usp.br/autopsy/article/view/189942
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author Ranjit I Kylat
author_facet Ranjit I Kylat
author_sort Ranjit I Kylat
collection DOAJ
description Extremely low birth weight (ELBW) infants are at particularly high risk for infection due to an immature immune system, invasive procedures such as endotracheal intubation, intravascular catheterization, and other factors. Neonatal infections in this population are associated with a high mortality, poor growth, and neurodevelopmental outcomes. Pseudomonas aeruginosa (P. aeruginosa) infection is an uncommon but potentially devastating cause of pneumonia and sepsis in the ELBW population. P. aeruginosa is an important cause of healthcare-associated infections (HAI) or nosocomial infections. P. aeruginosa can perceive unfavorable environmental changes and orchestrate adaptations by developing plasmid-mediated and adaptive resistance to antibiotics. We describe an ELBW infant born at 26 weeks’ gestation who succumbed at 13 days of life to P. aeruginosa infection. Some of the factors related to the pathogenesis and multidrug resistance are described.
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spelling doaj.art-dcf95e43a937493c89c4c0428d50e46b2022-12-21T17:15:59ZengUniversity of São PauloAutopsy and Case Reports2236-19602021-08-0111Pseudomonas aeruginosa necrotizing bronchopneumoniaRanjit I Kylat0University of Arizona, College of Medicine, Department of Pediatrics, Tucson, Arizona, USAExtremely low birth weight (ELBW) infants are at particularly high risk for infection due to an immature immune system, invasive procedures such as endotracheal intubation, intravascular catheterization, and other factors. Neonatal infections in this population are associated with a high mortality, poor growth, and neurodevelopmental outcomes. Pseudomonas aeruginosa (P. aeruginosa) infection is an uncommon but potentially devastating cause of pneumonia and sepsis in the ELBW population. P. aeruginosa is an important cause of healthcare-associated infections (HAI) or nosocomial infections. P. aeruginosa can perceive unfavorable environmental changes and orchestrate adaptations by developing plasmid-mediated and adaptive resistance to antibiotics. We describe an ELBW infant born at 26 weeks’ gestation who succumbed at 13 days of life to P. aeruginosa infection. Some of the factors related to the pathogenesis and multidrug resistance are described.https://www.revistas.usp.br/autopsy/article/view/189942Pseudomonas aeruginosaBronchopneumoniaInfantPrematureLow Birth WeightNeonatal Sepsis
spellingShingle Ranjit I Kylat
Pseudomonas aeruginosa necrotizing bronchopneumonia
Autopsy and Case Reports
Pseudomonas aeruginosa
Bronchopneumonia
Infant
Premature
Low Birth Weight
Neonatal Sepsis
title Pseudomonas aeruginosa necrotizing bronchopneumonia
title_full Pseudomonas aeruginosa necrotizing bronchopneumonia
title_fullStr Pseudomonas aeruginosa necrotizing bronchopneumonia
title_full_unstemmed Pseudomonas aeruginosa necrotizing bronchopneumonia
title_short Pseudomonas aeruginosa necrotizing bronchopneumonia
title_sort pseudomonas aeruginosa necrotizing bronchopneumonia
topic Pseudomonas aeruginosa
Bronchopneumonia
Infant
Premature
Low Birth Weight
Neonatal Sepsis
url https://www.revistas.usp.br/autopsy/article/view/189942
work_keys_str_mv AT ranjitikylat pseudomonasaeruginosanecrotizingbronchopneumonia