CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes
Chromosome segregation is essential to avoid aneuploidy, yet in mammalian oocytes it progressively fails in an age-dependent manner. Here the authors identify CENP-V as a microtubule binding and bundling protein crucial to faithful oocyte meiosis, and present Cenp-V−/− oocytes as revealing age-depen...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-26826-3 |
| _version_ | 1818932847932604416 |
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| author | Dalileh Nabi Hauke Drechsler Johannes Pschirer Franz Korn Nadine Schuler Stefan Diez Rolf Jessberger Mariola Chacón |
| author_facet | Dalileh Nabi Hauke Drechsler Johannes Pschirer Franz Korn Nadine Schuler Stefan Diez Rolf Jessberger Mariola Chacón |
| author_sort | Dalileh Nabi |
| collection | DOAJ |
| description | Chromosome segregation is essential to avoid aneuploidy, yet in mammalian oocytes it progressively fails in an age-dependent manner. Here the authors identify CENP-V as a microtubule binding and bundling protein crucial to faithful oocyte meiosis, and present Cenp-V−/− oocytes as revealing age-dependent weakening of the spindle assembly checkpoint. |
| first_indexed | 2024-12-20T04:39:00Z |
| format | Article |
| id | doaj.art-dcf979a98c334436b8bb21f92662b1b9 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T04:39:00Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dcf979a98c334436b8bb21f92662b1b92022-12-21T19:53:10ZengNature PortfolioNature Communications2041-17232021-11-0112111610.1038/s41467-021-26826-3CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytesDalileh Nabi0Hauke Drechsler1Johannes Pschirer2Franz Korn3Nadine Schuler4Stefan Diez5Rolf Jessberger6Mariola Chacón7Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität DresdenB CUBE-Center for Molecular Bioengineering, Technische Universität DresdenInstitute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität DresdenInstitute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität DresdenInstitute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität DresdenB CUBE-Center for Molecular Bioengineering, Technische Universität DresdenInstitute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität DresdenInstitute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technische Universität DresdenChromosome segregation is essential to avoid aneuploidy, yet in mammalian oocytes it progressively fails in an age-dependent manner. Here the authors identify CENP-V as a microtubule binding and bundling protein crucial to faithful oocyte meiosis, and present Cenp-V−/− oocytes as revealing age-dependent weakening of the spindle assembly checkpoint.https://doi.org/10.1038/s41467-021-26826-3 |
| spellingShingle | Dalileh Nabi Hauke Drechsler Johannes Pschirer Franz Korn Nadine Schuler Stefan Diez Rolf Jessberger Mariola Chacón CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes Nature Communications |
| title | CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes |
| title_full | CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes |
| title_fullStr | CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes |
| title_full_unstemmed | CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes |
| title_short | CENP-V is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes |
| title_sort | cenp v is required for proper chromosome segregation through interaction with spindle microtubules in mouse oocytes |
| url | https://doi.org/10.1038/s41467-021-26826-3 |
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