Nanomaterials for Protein Delivery in Anticancer Applications
Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles have been studied extensively for various drug deliveries, to treat or prevent diseases by modulating physiological or pathological processes. The delivery drug molecules range from traditional small molecules to re...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-01-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/13/2/155 |
| _version_ | 1797407737295929344 |
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| author | Anne Yau Jinhyung Lee Yupeng Chen |
| author_facet | Anne Yau Jinhyung Lee Yupeng Chen |
| author_sort | Anne Yau |
| collection | DOAJ |
| description | Nanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles have been studied extensively for various drug deliveries, to treat or prevent diseases by modulating physiological or pathological processes. The delivery drug molecules range from traditional small molecules to recently developed biologics, such as proteins, peptides, and nucleic acids. Among them, proteins have shown a series of advantages and potential in various therapeutic applications, such as introducing therapeutic proteins due to genetic defects, or used as nanocarriers for anticancer agents to decelerate tumor growth or control metastasis. This review discusses the existing nanoparticle delivery systems, introducing design strategies, advantages of using each system, and possible limitations. Moreover, we will examine the intracellular delivery of different protein therapeutics, such as antibodies, antigens, and gene editing proteins into the host cells to achieve anticancer effects and cancer vaccines. Finally, we explore the current applications of protein delivery in anticancer treatments. |
| first_indexed | 2024-03-09T03:45:56Z |
| format | Article |
| id | doaj.art-dcfa339977c44980903706c19c3da187 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T03:45:56Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-dcfa339977c44980903706c19c3da1872023-12-03T14:34:38ZengMDPI AGPharmaceutics1999-49232021-01-0113215510.3390/pharmaceutics13020155Nanomaterials for Protein Delivery in Anticancer ApplicationsAnne Yau0Jinhyung Lee1Yupeng Chen2Department of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USADepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USADepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USANanotechnology platforms, such as nanoparticles, liposomes, dendrimers, and micelles have been studied extensively for various drug deliveries, to treat or prevent diseases by modulating physiological or pathological processes. The delivery drug molecules range from traditional small molecules to recently developed biologics, such as proteins, peptides, and nucleic acids. Among them, proteins have shown a series of advantages and potential in various therapeutic applications, such as introducing therapeutic proteins due to genetic defects, or used as nanocarriers for anticancer agents to decelerate tumor growth or control metastasis. This review discusses the existing nanoparticle delivery systems, introducing design strategies, advantages of using each system, and possible limitations. Moreover, we will examine the intracellular delivery of different protein therapeutics, such as antibodies, antigens, and gene editing proteins into the host cells to achieve anticancer effects and cancer vaccines. Finally, we explore the current applications of protein delivery in anticancer treatments.https://www.mdpi.com/1999-4923/13/2/155nanomaterialsprotein deliveryanticancer therapycancer treatmentnanotechnology |
| spellingShingle | Anne Yau Jinhyung Lee Yupeng Chen Nanomaterials for Protein Delivery in Anticancer Applications Pharmaceutics nanomaterials protein delivery anticancer therapy cancer treatment nanotechnology |
| title | Nanomaterials for Protein Delivery in Anticancer Applications |
| title_full | Nanomaterials for Protein Delivery in Anticancer Applications |
| title_fullStr | Nanomaterials for Protein Delivery in Anticancer Applications |
| title_full_unstemmed | Nanomaterials for Protein Delivery in Anticancer Applications |
| title_short | Nanomaterials for Protein Delivery in Anticancer Applications |
| title_sort | nanomaterials for protein delivery in anticancer applications |
| topic | nanomaterials protein delivery anticancer therapy cancer treatment nanotechnology |
| url | https://www.mdpi.com/1999-4923/13/2/155 |
| work_keys_str_mv | AT anneyau nanomaterialsforproteindeliveryinanticancerapplications AT jinhyunglee nanomaterialsforproteindeliveryinanticancerapplications AT yupengchen nanomaterialsforproteindeliveryinanticancerapplications |