Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer
Abstract Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2019-03-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-019-0960-z |
| _version_ | 1818279867660107776 |
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| author | Jana Plava Marina Cihova Monika Burikova Miroslava Matuskova Lucia Kucerova Svetlana Miklikova |
| author_facet | Jana Plava Marina Cihova Monika Burikova Miroslava Matuskova Lucia Kucerova Svetlana Miklikova |
| author_sort | Jana Plava |
| collection | DOAJ |
| description | Abstract Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts. The bi-directional interactions between tumor and stromal cells therefore substantially affect tumor cell biology. Herein, we discuss current available information on these interactions in breast cancer chemo-resistance. It is acknowledged that stromal cells extrinsically alter tumor cell drug responses with profound consequences for therapy efficiency, and it is therefore essential to understand the molecular mechanisms which contribute to these substantial alterations because they provide potential targets for improved cancer therapy. Although breast cancer patient survival has improved over the last decades, chemo-resistance still remains a significant obstacle to successful treatment. Appreciating the important experimental evidence of mesenchymal stromal cells and cancer-associated fibroblast involvement in breast cancer clinical practice can therefore have important therapeutic implications. |
| first_indexed | 2024-12-12T23:40:09Z |
| format | Article |
| id | doaj.art-dcfb0fb8d2144b0fb9d029ac4898e8f8 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-12-12T23:40:09Z |
| publishDate | 2019-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-dcfb0fb8d2144b0fb9d029ac4898e8f82022-12-22T00:07:14ZengBMCMolecular Cancer1476-45982019-03-0118111010.1186/s12943-019-0960-zRecent advances in understanding tumor stroma-mediated chemoresistance in breast cancerJana Plava0Marina Cihova1Monika Burikova2Miroslava Matuskova3Lucia Kucerova4Svetlana Miklikova5Cancer Research Institute, Biomedical Research Center, Slovak Academy of SciencesCancer Research Institute, Biomedical Research Center, Slovak Academy of SciencesCancer Research Institute, Biomedical Research Center, Slovak Academy of SciencesCancer Research Institute, Biomedical Research Center, Slovak Academy of SciencesCancer Research Institute, Biomedical Research Center, Slovak Academy of SciencesCancer Research Institute, Biomedical Research Center, Slovak Academy of SciencesAbstract Although solid tumors comprise malignant cells, they also contain many different non-malignant cell types in their micro-environment. The cellular components of the tumor stroma consist of immune and endothelial cells combined with a heterogeneous population of stromal cells which include cancer-associated fibroblasts. The bi-directional interactions between tumor and stromal cells therefore substantially affect tumor cell biology. Herein, we discuss current available information on these interactions in breast cancer chemo-resistance. It is acknowledged that stromal cells extrinsically alter tumor cell drug responses with profound consequences for therapy efficiency, and it is therefore essential to understand the molecular mechanisms which contribute to these substantial alterations because they provide potential targets for improved cancer therapy. Although breast cancer patient survival has improved over the last decades, chemo-resistance still remains a significant obstacle to successful treatment. Appreciating the important experimental evidence of mesenchymal stromal cells and cancer-associated fibroblast involvement in breast cancer clinical practice can therefore have important therapeutic implications.http://link.springer.com/article/10.1186/s12943-019-0960-zBreast cancerChemo-resistanceMolecular mechanismsTumor stromaMesenchymal stromal cells |
| spellingShingle | Jana Plava Marina Cihova Monika Burikova Miroslava Matuskova Lucia Kucerova Svetlana Miklikova Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer Molecular Cancer Breast cancer Chemo-resistance Molecular mechanisms Tumor stroma Mesenchymal stromal cells |
| title | Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer |
| title_full | Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer |
| title_fullStr | Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer |
| title_full_unstemmed | Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer |
| title_short | Recent advances in understanding tumor stroma-mediated chemoresistance in breast cancer |
| title_sort | recent advances in understanding tumor stroma mediated chemoresistance in breast cancer |
| topic | Breast cancer Chemo-resistance Molecular mechanisms Tumor stroma Mesenchymal stromal cells |
| url | http://link.springer.com/article/10.1186/s12943-019-0960-z |
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