Role of lipoprotein lipase variants in metabolic disorders and cardiovascular diseases
Lipoprotein lipase (LPL) is a glycoprotein that is produced and secreted into the interstitial space in various tissues, including the cardiac muscle, adipose tissue, macrophages, and skeletal muscle. LPL activity could be affected by genetic alterations which result in changes in lipid metabolism....
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| Format: | Article |
| Language: | srp |
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Pharmaceutical Association of Serbia, Belgrade, Serbia
2024-01-01
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| Series: | Arhiv za farmaciju |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632401038R.pdf |
| _version_ | 1827293621475344384 |
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| author | Rafaqat Sana Rafaqat Saira Sharif Saima Klisić Aleksandra |
| author_facet | Rafaqat Sana Rafaqat Saira Sharif Saima Klisić Aleksandra |
| author_sort | Rafaqat Sana |
| collection | DOAJ |
| description | Lipoprotein lipase (LPL) is a glycoprotein that is produced and secreted into the interstitial space in various tissues, including the cardiac muscle, adipose tissue, macrophages, and skeletal muscle. LPL activity could be affected by genetic alterations which result in changes in lipid metabolism. This review article only focuses on reporting the recent studies which mainly explain the role of the LPL gene variants in metabolic syndrome and cardiovascular diseases. There are over 100 LPL gene variants, but this review article reported rs1801177, rs118204069, rs118204057, rs118204060, rs118204068, rs268, and rs328 as the most common in metabolic syndrome patients. In cardiovascular diseases, LPL variants rs1801177, rs268 and rs328 were the most prevalent. Therefore, it is suggested that further studies should be conducted to identify the LPL gene variants in other cardiovascular diseases, including cardiac arrhythmia. This review article concludes that LPL deficiency and dysfunction are associated with many diseases, such as obesity, insulin resistance, diabetes, chylomicronemia, atherosclerosis, myocardial infarction, coronary artery disease, and stroke. |
| first_indexed | 2024-04-24T13:42:14Z |
| format | Article |
| id | doaj.art-dcfea8128fd44e1d976ea977c14a6e62 |
| institution | Directory Open Access Journal |
| issn | 0004-1963 2217-8767 |
| language | srp |
| last_indexed | 2024-04-24T13:42:14Z |
| publishDate | 2024-01-01 |
| publisher | Pharmaceutical Association of Serbia, Belgrade, Serbia |
| record_format | Article |
| series | Arhiv za farmaciju |
| spelling | doaj.art-dcfea8128fd44e1d976ea977c14a6e622024-04-04T08:11:07ZsrpPharmaceutical Association of Serbia, Belgrade, SerbiaArhiv za farmaciju0004-19632217-87672024-01-01741385510.5937/arhfarm74-480700004-19632401038RRole of lipoprotein lipase variants in metabolic disorders and cardiovascular diseasesRafaqat Sana0Rafaqat Saira1Sharif Saima2Klisić Aleksandra3https://orcid.org/0000-0001-7870-0996Lahore College for Women University, Department of Biotechnology (Human Genetics), Lahore, Punjab, PakistanLahore College for Women University, Department of Zoology (Molecular Physiology), Lahore, Punjab, PakistanLahore College for Women University, Department of Zoology (Molecular Physiology), Lahore, Punjab, PakistanUniversity of Montenegro, Faculty of Medicine, Podgorica, MontenegroLipoprotein lipase (LPL) is a glycoprotein that is produced and secreted into the interstitial space in various tissues, including the cardiac muscle, adipose tissue, macrophages, and skeletal muscle. LPL activity could be affected by genetic alterations which result in changes in lipid metabolism. This review article only focuses on reporting the recent studies which mainly explain the role of the LPL gene variants in metabolic syndrome and cardiovascular diseases. There are over 100 LPL gene variants, but this review article reported rs1801177, rs118204069, rs118204057, rs118204060, rs118204068, rs268, and rs328 as the most common in metabolic syndrome patients. In cardiovascular diseases, LPL variants rs1801177, rs268 and rs328 were the most prevalent. Therefore, it is suggested that further studies should be conducted to identify the LPL gene variants in other cardiovascular diseases, including cardiac arrhythmia. This review article concludes that LPL deficiency and dysfunction are associated with many diseases, such as obesity, insulin resistance, diabetes, chylomicronemia, atherosclerosis, myocardial infarction, coronary artery disease, and stroke.https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632401038R.pdflipoprotein lipasemetabolic syndromecardiovascular diseasespathophysiologymutation |
| spellingShingle | Rafaqat Sana Rafaqat Saira Sharif Saima Klisić Aleksandra Role of lipoprotein lipase variants in metabolic disorders and cardiovascular diseases Arhiv za farmaciju lipoprotein lipase metabolic syndrome cardiovascular diseases pathophysiology mutation |
| title | Role of lipoprotein lipase variants in metabolic disorders and cardiovascular diseases |
| title_full | Role of lipoprotein lipase variants in metabolic disorders and cardiovascular diseases |
| title_fullStr | Role of lipoprotein lipase variants in metabolic disorders and cardiovascular diseases |
| title_full_unstemmed | Role of lipoprotein lipase variants in metabolic disorders and cardiovascular diseases |
| title_short | Role of lipoprotein lipase variants in metabolic disorders and cardiovascular diseases |
| title_sort | role of lipoprotein lipase variants in metabolic disorders and cardiovascular diseases |
| topic | lipoprotein lipase metabolic syndrome cardiovascular diseases pathophysiology mutation |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0004-1963/2024/0004-19632401038R.pdf |
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