Functional complementation of a yeast knockout strain by Schistosoma mansoni Rho1 GTPase in the presence of caffeine, an agent that affects mutants defective in the protein kinase C signal transduction pathway

Functional complementation of a yeast knockout strain by Schistosoma mansoni Rho1 GTPase in the presence of caffeine, an agent that affects mutants defective in the protein kinase C signal transduction pathway

In a previous study, the Schistosoma mansoni Rho1 protein was able to complement Rho1 null mutant Saccharomyces cerevisiae cells at restrictive temperatures and under osmotic stress (low calcium concentration) better than the human homologue (RhoA). It is known that under osmotic stress, the S. cere...

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Bibliographic Details
Main Authors: Pedro HN de Aguiar, Débora N Santos, Francisco P Lobo, Túlio M Santos, Andréa M Macedo, Sérgio DJ Pena, Carlos R Machado, Glória R Franco
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2006-10-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
Schistosoma mansoni
SmRho1
protein kinase C1
caffeine
Saccharomyces cerevisiae
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000900051

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000900051

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