Expression of Immunotherapy Target PRAME in Cancer Correlates with Histone H3 Acetylation and Is Unrelated to Expression of Methylating (DMNT3A/3B) and Demethylating (TET1) Enzymes

Expression of Immunotherapy Target PRAME in Cancer Correlates with Histone H3 Acetylation and Is Unrelated to Expression of Methylating (DMNT3A/3B) and Demethylating (TET1) Enzymes

<b>Background/Objectives:</b> Preferentially expressed antigen in melanoma (PRAME), a member of the cancer testis antigen family, is a promising target for cancer immunotherapy. Understanding the epigenetic mechanisms involved in the regulation of PRAME expression might be crucial for op...

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Bibliographic Details
Main Authors: Maciej Kaczorowski, Jerzy Lasota, Krzysztof Dudek, Bartosz Małkiewicz, Markku Miettinen, Agnieszka Hałoń
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Journal of Clinical Medicine
Subjects:
PRAME
TET1
DNMT3A
DNMT3B
5hmC
H3ac
Online Access:https://www.mdpi.com/2077-0383/13/6/1554

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