Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond
Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight kininogens (HKs and LKs) as substrates, releasing brady...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2023.1188816/full |
| _version_ | 1797730980580032512 |
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| author | Guacyara Motta Luiz Juliano Jair Ribeiro Chagas |
| author_facet | Guacyara Motta Luiz Juliano Jair Ribeiro Chagas |
| author_sort | Guacyara Motta |
| collection | DOAJ |
| description | Human plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight kininogens (HKs and LKs) as substrates, releasing bradykinin (Bk) and Lys-bradykinin (Lys-Bk), respectively. This review presents a brief history of human PKa with details and recent observations of its evolution among the vertebrate coagulation proteins, including the relations with Factor XI. We explored the role of Factor XII in activating the plasma kallikrein–kinin system (KKS), the mechanism of activity and control in the KKS, and the function of HK on contact activation proteins on cell membranes. The role of human PKa in cell biology regarding the contact system and KSS, particularly the endothelial cells, and neutrophils, in inflammatory processes and infectious diseases, was also approached. We examined the natural plasma protein inhibitors, including a detailed survey of human PKa inhibitors’ development and their potential market. |
| first_indexed | 2024-03-12T11:51:59Z |
| format | Article |
| id | doaj.art-dcffebaa0d9848f7a41e51bbddcb87d5 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-03-12T11:51:59Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-dcffebaa0d9848f7a41e51bbddcb87d52023-08-31T06:45:17ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2023-08-011410.3389/fphys.2023.11888161188816Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyondGuacyara Motta0Luiz Juliano1Jair Ribeiro Chagas2Departamento de Bioquímica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilDepartamento de Biofisica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilDepartamento de Biofisica, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, BrazilHuman plasma kallikrein (PKa) is obtained by activating its precursor, prekallikrein (PK), historically named the Fletcher factor. Human PKa and tissue kallikreins are serine proteases from the same family, having high- and low-molecular weight kininogens (HKs and LKs) as substrates, releasing bradykinin (Bk) and Lys-bradykinin (Lys-Bk), respectively. This review presents a brief history of human PKa with details and recent observations of its evolution among the vertebrate coagulation proteins, including the relations with Factor XI. We explored the role of Factor XII in activating the plasma kallikrein–kinin system (KKS), the mechanism of activity and control in the KKS, and the function of HK on contact activation proteins on cell membranes. The role of human PKa in cell biology regarding the contact system and KSS, particularly the endothelial cells, and neutrophils, in inflammatory processes and infectious diseases, was also approached. We examined the natural plasma protein inhibitors, including a detailed survey of human PKa inhibitors’ development and their potential market.https://www.frontiersin.org/articles/10.3389/fphys.2023.1188816/fullbradykininkininogenkallikreinproteolysiscell biologyinflammation |
| spellingShingle | Guacyara Motta Luiz Juliano Jair Ribeiro Chagas Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond Frontiers in Physiology bradykinin kininogen kallikrein proteolysis cell biology inflammation |
| title | Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond |
| title_full | Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond |
| title_fullStr | Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond |
| title_full_unstemmed | Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond |
| title_short | Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond |
| title_sort | human plasma kallikrein roles in coagulation fibrinolysis inflammation pathways and beyond |
| topic | bradykinin kininogen kallikrein proteolysis cell biology inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2023.1188816/full |
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