Mechanoresponsive regulation of fibroblast-to-myofibroblast transition in three-dimensional tissue analogues: mechanical strain amplitude dependency of fibrosis
Abstract The spatiotemporal interaction and constant iterative feedback between fibroblasts, extracellular matrix, and environmental cues are central for investigating the fibroblast-induced musculoskeletal tissue regeneration and fibroblast-to-myofibroblast transition (FMT). In this study, we creat...
Main Authors: | Diego Jacho, Agustin Rabino, Rafael Garcia-Mata, Eda Yildirim-Ayan |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-10-01
|
Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-022-20383-5 |
Similar Items
-
Modulating TRPV4 Channel Activity in Pro-Inflammatory Macrophages within the 3D Tissue Analog
by: Parto Babaniamansour, et al.
Published: (2024-01-01) -
Noncoding RNAs: Master Regulator of Fibroblast to Myofibroblast Transition in Fibrosis
by: Huamin Zhang, et al.
Published: (2023-01-01) -
Mechanoresponsive Flexible Crystals
by: Zhihua Wang, et al.
Published: (2024-01-01) -
GDF15 Modulates the Zoledronic-Acid-Induced Hyperinflammatory Mechanoresponse of Periodontal Ligament Fibroblasts
by: Ann Nitzsche, et al.
Published: (2024-01-01) -
Collagen VI Deficiency Impairs Tendon Fibroblasts Mechanoresponse in Ullrich Congenital Muscular Dystrophy
by: Vittoria Cenni, et al.
Published: (2024-02-01)