Uncommon presentation of small cell lung carcinoma with ectopic adrenocorticotropic hormone secretion and resistant hypokalemia: A case report
Paraneoplastic syndromes can serve as initial indicators of malignancy, with small cell lung cancer accounting for 13% of new lung cancer diagnoses. The most prevalent paraneoplastic syndrome associated with small cell lung cancer is inappropriate antidiuretic hormone syndrome, followed by ectopic...
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| Format: | Article |
| Language: | English |
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State Institution «Institute of Nephrology NAMS of Ukraine"
2023-12-01
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| Series: | Український Журнал Нефрології та Діалізу |
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| Online Access: | https://ukrjnd.com.ua/index.php/journal/article/view/785 |
| _version_ | 1797262273292533760 |
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| author | Esra Geçgel Alper Alp Emel Kılıçarslan Karpuzoğlu Dilek Gibyeli Genek Bülent Huddam |
| author_facet | Esra Geçgel Alper Alp Emel Kılıçarslan Karpuzoğlu Dilek Gibyeli Genek Bülent Huddam |
| author_sort | Esra Geçgel |
| collection | DOAJ |
| description |
Paraneoplastic syndromes can serve as initial indicators of malignancy, with small cell lung cancer accounting for 13% of new lung cancer diagnoses. The most prevalent paraneoplastic syndrome associated with small cell lung cancer is inappropriate antidiuretic hormone syndrome, followed by ectopic adrenocorticotropic hormone-mediated Cushing’s syndrome. Cushing’s syndrome manifests as hypercortisolemia and presents with diverse symptoms, including central obesity, plethora, menstrual irregularities, hypertension/diabetes mellitus, ecchymoses, osteoporosis, muscle weakness, virilization/hirsutism, skin atrophy, decreased libido, and infertility. This case report details the uncommon presentation of small cell lung carcinoma manifesting with ectopic adrenocorticotropic hormone secretion (EAS), leading to resistant hypokalemia and rhabdomyolysis. This case emphasizes the importance of considering EAS in severe cases of Cushing's syndrome and highlights the diagnostic and therapeutic challenges associated with this condition.
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| first_indexed | 2024-04-24T23:54:29Z |
| format | Article |
| id | doaj.art-dd015e2106a84a8a9e7292e567786a9c |
| institution | Directory Open Access Journal |
| issn | 2304-0238 2616-7352 |
| language | English |
| last_indexed | 2024-04-24T23:54:29Z |
| publishDate | 2023-12-01 |
| publisher | State Institution «Institute of Nephrology NAMS of Ukraine" |
| record_format | Article |
| series | Український Журнал Нефрології та Діалізу |
| spelling | doaj.art-dd015e2106a84a8a9e7292e567786a9c2024-03-14T16:51:12ZengState Institution «Institute of Nephrology NAMS of Ukraine"Український Журнал Нефрології та Діалізу2304-02382616-73522023-12-011(81)10.31450/ukrjnd.1(81).2024.01Uncommon presentation of small cell lung carcinoma with ectopic adrenocorticotropic hormone secretion and resistant hypokalemia: A case reportEsra Geçgel0Alper Alp1Emel Kılıçarslan Karpuzoğlu2Dilek Gibyeli Genek3Bülent Huddam4Department of Internal Medicine, Faculty of Medicine, Mugla Sıtkı Koçman University, Mugla, TurkeyDepartment of Nephrology, Faculty of Medicine, Mugla Sıtkı Koçman University, Mugla, TurkeyDepartment of Pathology, Faculty of Medicine, Pamukkkale University, Denizli, TurkeyDepartment of Nephrology, Faculty of Medicine, Mugla Sıtkı Koçman University, Mugla, TurkeyDepartment of Nephrology, Faculty of Medicine, Mugla Sıtkı Koçman University, Mugla, Turkey. Paraneoplastic syndromes can serve as initial indicators of malignancy, with small cell lung cancer accounting for 13% of new lung cancer diagnoses. The most prevalent paraneoplastic syndrome associated with small cell lung cancer is inappropriate antidiuretic hormone syndrome, followed by ectopic adrenocorticotropic hormone-mediated Cushing’s syndrome. Cushing’s syndrome manifests as hypercortisolemia and presents with diverse symptoms, including central obesity, plethora, menstrual irregularities, hypertension/diabetes mellitus, ecchymoses, osteoporosis, muscle weakness, virilization/hirsutism, skin atrophy, decreased libido, and infertility. This case report details the uncommon presentation of small cell lung carcinoma manifesting with ectopic adrenocorticotropic hormone secretion (EAS), leading to resistant hypokalemia and rhabdomyolysis. This case emphasizes the importance of considering EAS in severe cases of Cushing's syndrome and highlights the diagnostic and therapeutic challenges associated with this condition. https://ukrjnd.com.ua/index.php/journal/article/view/785Small cell lung cancerCushing’s syndromeHypokalemia |
| spellingShingle | Esra Geçgel Alper Alp Emel Kılıçarslan Karpuzoğlu Dilek Gibyeli Genek Bülent Huddam Uncommon presentation of small cell lung carcinoma with ectopic adrenocorticotropic hormone secretion and resistant hypokalemia: A case report Український Журнал Нефрології та Діалізу Small cell lung cancer Cushing’s syndrome Hypokalemia |
| title | Uncommon presentation of small cell lung carcinoma with ectopic adrenocorticotropic hormone secretion and resistant hypokalemia: A case report |
| title_full | Uncommon presentation of small cell lung carcinoma with ectopic adrenocorticotropic hormone secretion and resistant hypokalemia: A case report |
| title_fullStr | Uncommon presentation of small cell lung carcinoma with ectopic adrenocorticotropic hormone secretion and resistant hypokalemia: A case report |
| title_full_unstemmed | Uncommon presentation of small cell lung carcinoma with ectopic adrenocorticotropic hormone secretion and resistant hypokalemia: A case report |
| title_short | Uncommon presentation of small cell lung carcinoma with ectopic adrenocorticotropic hormone secretion and resistant hypokalemia: A case report |
| title_sort | uncommon presentation of small cell lung carcinoma with ectopic adrenocorticotropic hormone secretion and resistant hypokalemia a case report |
| topic | Small cell lung cancer Cushing’s syndrome Hypokalemia |
| url | https://ukrjnd.com.ua/index.php/journal/article/view/785 |
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