Methods to Identify Cognitive Alterations from Animals to Humans: A Translational Approach
The increasing prevalence of cognitive dysfunction and dementia in developed countries, associated with population aging, has generated great interest in characterizing and quantifying cognitive deficits in these patients. An essential tool for accurate diagnosis is cognitive assessment, a lengthy p...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/8/7653 |
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| author | Daniela Navarro Ani Gasparyan Silvia Martí Martínez Carmen Díaz Marín Francisco Navarrete María Salud García Gutiérrez Jorge Manzanares |
| author_facet | Daniela Navarro Ani Gasparyan Silvia Martí Martínez Carmen Díaz Marín Francisco Navarrete María Salud García Gutiérrez Jorge Manzanares |
| author_sort | Daniela Navarro |
| collection | DOAJ |
| description | The increasing prevalence of cognitive dysfunction and dementia in developed countries, associated with population aging, has generated great interest in characterizing and quantifying cognitive deficits in these patients. An essential tool for accurate diagnosis is cognitive assessment, a lengthy process that depends on the cognitive domains analyzed. Cognitive tests, functional capacity scales, and advanced neuroimaging studies explore the different mental functions in clinical practice. On the other hand, animal models of human diseases with cognitive impairment are essential for understanding disease pathophysiology. The study of cognitive function using animal models encompasses multiple dimensions, and deciding which ones to investigate is necessary to select the most appropriate and specific tests. Therefore, this review studies the main cognitive tests for assessing cognitive deficits in patients with neurodegenerative diseases. Cognitive tests, the most commonly used functional capacity scales, and those resulting from previous evidence are considered. In addition, the leading behavioral tests that assess cognitive functions in animal models of disorders with cognitive impairment are highlighted. |
| first_indexed | 2024-03-11T04:55:32Z |
| format | Article |
| id | doaj.art-dd03b4f42bcd4b9d8da0d86105e373ab |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T04:55:32Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-dd03b4f42bcd4b9d8da0d86105e373ab2023-11-17T19:43:40ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01248765310.3390/ijms24087653Methods to Identify Cognitive Alterations from Animals to Humans: A Translational ApproachDaniela Navarro0Ani Gasparyan1Silvia Martí Martínez2Carmen Díaz Marín3Francisco Navarrete4María Salud García Gutiérrez5Jorge Manzanares6Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, SpainInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, SpainInstituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), 03010 Alicante, SpainInstituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), 03010 Alicante, SpainInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, SpainInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, SpainInstituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, SpainThe increasing prevalence of cognitive dysfunction and dementia in developed countries, associated with population aging, has generated great interest in characterizing and quantifying cognitive deficits in these patients. An essential tool for accurate diagnosis is cognitive assessment, a lengthy process that depends on the cognitive domains analyzed. Cognitive tests, functional capacity scales, and advanced neuroimaging studies explore the different mental functions in clinical practice. On the other hand, animal models of human diseases with cognitive impairment are essential for understanding disease pathophysiology. The study of cognitive function using animal models encompasses multiple dimensions, and deciding which ones to investigate is necessary to select the most appropriate and specific tests. Therefore, this review studies the main cognitive tests for assessing cognitive deficits in patients with neurodegenerative diseases. Cognitive tests, the most commonly used functional capacity scales, and those resulting from previous evidence are considered. In addition, the leading behavioral tests that assess cognitive functions in animal models of disorders with cognitive impairment are highlighted.https://www.mdpi.com/1422-0067/24/8/7653human cognitive trialsdementiacognitive impairmentmemoryanimal models |
| spellingShingle | Daniela Navarro Ani Gasparyan Silvia Martí Martínez Carmen Díaz Marín Francisco Navarrete María Salud García Gutiérrez Jorge Manzanares Methods to Identify Cognitive Alterations from Animals to Humans: A Translational Approach International Journal of Molecular Sciences human cognitive trials dementia cognitive impairment memory animal models |
| title | Methods to Identify Cognitive Alterations from Animals to Humans: A Translational Approach |
| title_full | Methods to Identify Cognitive Alterations from Animals to Humans: A Translational Approach |
| title_fullStr | Methods to Identify Cognitive Alterations from Animals to Humans: A Translational Approach |
| title_full_unstemmed | Methods to Identify Cognitive Alterations from Animals to Humans: A Translational Approach |
| title_short | Methods to Identify Cognitive Alterations from Animals to Humans: A Translational Approach |
| title_sort | methods to identify cognitive alterations from animals to humans a translational approach |
| topic | human cognitive trials dementia cognitive impairment memory animal models |
| url | https://www.mdpi.com/1422-0067/24/8/7653 |
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