Colorectal cancer among inflammatory bowel disease patients: risk factors and prevalence compared to the general population
BackgroundColorectal cancer (CRC) is a feared complication of inflammatory bowel disease (IBD). We aimed to investigate the prevalence and risk factors of CRC among a large cohort of IBD patients.MethodsData on IBD patients free of CRC at baseline was extracted using the MDClone platform of the Clal...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1225616/full |
| _version_ | 1797751264455426048 |
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| author | Naim Abu-Freha Naim Abu-Freha Bracha Cohen Michal Gordon Sarah Weissmann Sarah Weissmann Emily H. Kestenbaum Sergei Vosko Muhammad Abu-Tailakh Muhammad Abu-Tailakh Liza Ben-Shoshan Daniel L. Cohen Haim Shirin |
| author_facet | Naim Abu-Freha Naim Abu-Freha Bracha Cohen Michal Gordon Sarah Weissmann Sarah Weissmann Emily H. Kestenbaum Sergei Vosko Muhammad Abu-Tailakh Muhammad Abu-Tailakh Liza Ben-Shoshan Daniel L. Cohen Haim Shirin |
| author_sort | Naim Abu-Freha |
| collection | DOAJ |
| description | BackgroundColorectal cancer (CRC) is a feared complication of inflammatory bowel disease (IBD). We aimed to investigate the prevalence and risk factors of CRC among a large cohort of IBD patients.MethodsData on IBD patients free of CRC at baseline was extracted using the MDClone platform of the Clalit health maintenance organization in Israel. We investigated the frequency rate of CRC among IBD patients compared to a control group without IBD. Possible risk factors, including comorbidities and IBD-related medications, were investigated in a multivariate analysis.ResultsDuring a follow-up of 139,448 years among Crohn’s disease (CD) patients and 139,533 years among ulcerative colitis (UC) patients, a frequency rate of CRC was 1.5% (191) among 12,888 CD patients and 2.1% (261) among 12,381 UC patients compared to 1.2% among 57,334 controls. In a multivariate analysis of UC patients, age at diagnosis (OR 1.030, p < 0.001), primary sclerosing cholangitis (OR 2.487, p = 0.005), diabetes mellitus (OR 2.01, p < 0.001), and glucocorticoids treatment (OR 1.465, p = 0.008) were found to be predictors of CRC. For CD patients, age at diagnosis (OR 1.035, p < 0.001), primary sclerosing cholangitis (OR 2.25, p = 0.029), and glucocorticoids treatment (OR 2.07, p < 0.001) were found to be predictors for CRC, but not diabetes mellitus.ConclusionDespite the continuously decreasing rates of CRC among IBD patients, these are still higher in IBD patients compared to the general population. IBD patients, particularly those with risk factors, require special consideration in follow-up for CRC. |
| first_indexed | 2024-03-12T16:46:00Z |
| format | Article |
| id | doaj.art-dd03dae9fc374ba4b6b9a9b2f6b0304d |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-12T16:46:00Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-dd03dae9fc374ba4b6b9a9b2f6b0304d2023-08-08T14:04:14ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-08-011010.3389/fmed.2023.12256161225616Colorectal cancer among inflammatory bowel disease patients: risk factors and prevalence compared to the general populationNaim Abu-Freha0Naim Abu-Freha1Bracha Cohen2Michal Gordon3Sarah Weissmann4Sarah Weissmann5Emily H. Kestenbaum6Sergei Vosko7Muhammad Abu-Tailakh8Muhammad Abu-Tailakh9Liza Ben-Shoshan10Daniel L. Cohen11Haim Shirin12The Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Beer-Sheva, IsraelThe Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelSoroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva, IsraelSoroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva, IsraelThe Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelSoroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva, IsraelMedical School for International Health, Ben-Gurion University of the Negev, Beer-Sheva, IsraelThe Gonczarowski Family Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, The Sackler School of Medicine, Tel Aviv University, Zerifin, IsraelRecanati School for Community Health Professions, Department of Nursing, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelSoroka University Medical Center, Beer-Sheva, IsraelThe Institute of Gastroenterology and Hepatology, Soroka University Medical Center, Beer-Sheva, IsraelThe Gonczarowski Family Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, The Sackler School of Medicine, Tel Aviv University, Zerifin, IsraelThe Gonczarowski Family Institute of Gastroenterology and Liver Diseases, Shamir (Assaf Harofeh) Medical Center, The Sackler School of Medicine, Tel Aviv University, Zerifin, IsraelBackgroundColorectal cancer (CRC) is a feared complication of inflammatory bowel disease (IBD). We aimed to investigate the prevalence and risk factors of CRC among a large cohort of IBD patients.MethodsData on IBD patients free of CRC at baseline was extracted using the MDClone platform of the Clalit health maintenance organization in Israel. We investigated the frequency rate of CRC among IBD patients compared to a control group without IBD. Possible risk factors, including comorbidities and IBD-related medications, were investigated in a multivariate analysis.ResultsDuring a follow-up of 139,448 years among Crohn’s disease (CD) patients and 139,533 years among ulcerative colitis (UC) patients, a frequency rate of CRC was 1.5% (191) among 12,888 CD patients and 2.1% (261) among 12,381 UC patients compared to 1.2% among 57,334 controls. In a multivariate analysis of UC patients, age at diagnosis (OR 1.030, p < 0.001), primary sclerosing cholangitis (OR 2.487, p = 0.005), diabetes mellitus (OR 2.01, p < 0.001), and glucocorticoids treatment (OR 1.465, p = 0.008) were found to be predictors of CRC. For CD patients, age at diagnosis (OR 1.035, p < 0.001), primary sclerosing cholangitis (OR 2.25, p = 0.029), and glucocorticoids treatment (OR 2.07, p < 0.001) were found to be predictors for CRC, but not diabetes mellitus.ConclusionDespite the continuously decreasing rates of CRC among IBD patients, these are still higher in IBD patients compared to the general population. IBD patients, particularly those with risk factors, require special consideration in follow-up for CRC.https://www.frontiersin.org/articles/10.3389/fmed.2023.1225616/fullcolorectal cancerCrohn’s diseaseulcerative colitisinflammatory bowel diseaserisk factors |
| spellingShingle | Naim Abu-Freha Naim Abu-Freha Bracha Cohen Michal Gordon Sarah Weissmann Sarah Weissmann Emily H. Kestenbaum Sergei Vosko Muhammad Abu-Tailakh Muhammad Abu-Tailakh Liza Ben-Shoshan Daniel L. Cohen Haim Shirin Colorectal cancer among inflammatory bowel disease patients: risk factors and prevalence compared to the general population Frontiers in Medicine colorectal cancer Crohn’s disease ulcerative colitis inflammatory bowel disease risk factors |
| title | Colorectal cancer among inflammatory bowel disease patients: risk factors and prevalence compared to the general population |
| title_full | Colorectal cancer among inflammatory bowel disease patients: risk factors and prevalence compared to the general population |
| title_fullStr | Colorectal cancer among inflammatory bowel disease patients: risk factors and prevalence compared to the general population |
| title_full_unstemmed | Colorectal cancer among inflammatory bowel disease patients: risk factors and prevalence compared to the general population |
| title_short | Colorectal cancer among inflammatory bowel disease patients: risk factors and prevalence compared to the general population |
| title_sort | colorectal cancer among inflammatory bowel disease patients risk factors and prevalence compared to the general population |
| topic | colorectal cancer Crohn’s disease ulcerative colitis inflammatory bowel disease risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1225616/full |
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