Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome
Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in burning mouth syndrome (BMS) patients. Methods: Ser...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-12-01
|
| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664620304095 |
| _version_ | 1818400078575960064 |
|---|---|
| author | Chun-Pin Chiang Yang-Che Wu Yu-Hsueh Wu Julia Yu-Fong Chang Yi-Ping Wang Andy Sun |
| author_facet | Chun-Pin Chiang Yang-Che Wu Yu-Hsueh Wu Julia Yu-Fong Chang Yi-Ping Wang Andy Sun |
| author_sort | Chun-Pin Chiang |
| collection | DOAJ |
| description | Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in burning mouth syndrome (BMS) patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 884 BMS patients and in 442 age- and sex-matched healthy control subjects. Results: We found that 12.3%, 21.6%, and 22.7% of 884 BMS patients and 1.8%, 2.3%, and 2.9% of 442 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. BMS patients had significantly higher frequencies of GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). We also found that 20 (2.3%), 130 (14.7%), and 181 (20.5%) BMS patients and 3 (0.7%), 8 (1.8%), and 6 (1.4%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 255 TGA/TMA-positive BMS patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 87.8%, 5.1%, and 7.1% of these TGA/TMA-positive BMS patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: Approximately 37.5% of 884 BMS patients have serum GPCA/TGA/TMA positivity. Moreover, 12.3%, 21.6%, and 22.7% of 884 BMS patients have the serum GPCA, TGA, and TMA positivities, respectively. Only 5.1% and 7.1% of TGA/TMA-positive BMS patients have hyperthyroidism and hypothyroidism, respectively. It needs further studies to know whether GPCA-positive BMS patients may finally become as having autoimmune atrophic gastritis. |
| first_indexed | 2024-12-14T07:30:51Z |
| format | Article |
| id | doaj.art-dd03f5d8c4cd40f3827c352bffb56105 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-14T07:30:51Z |
| publishDate | 2020-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-dd03f5d8c4cd40f3827c352bffb561052022-12-21T23:11:22ZengElsevierJournal of the Formosan Medical Association0929-66462020-12-011191217581763Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndromeChun-Pin Chiang0Yang-Che Wu1Yu-Hsueh Wu2Julia Yu-Fong Chang3Yi-Ping Wang4Andy Sun5Department of Dentistry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan; Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, TaiwanSchool of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan; Department of Dentistry, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei City, TaiwanDepartment of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, TaiwanGraduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Corresponding author. Department of Dentistry, National Taiwan University Hospital, No. 1, Chang-Te Street, Taipei 10048, Taiwan. Fax: +886 02 2389 3853.Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) are organ-specific autoantibodies. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in burning mouth syndrome (BMS) patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 884 BMS patients and in 442 age- and sex-matched healthy control subjects. Results: We found that 12.3%, 21.6%, and 22.7% of 884 BMS patients and 1.8%, 2.3%, and 2.9% of 442 healthy control subjects had the serum GPCA, TGA, and TMA positivities, respectively. BMS patients had significantly higher frequencies of GPCA, TGA, and TMA positivities than healthy control subjects (all P-values < 0.001). We also found that 20 (2.3%), 130 (14.7%), and 181 (20.5%) BMS patients and 3 (0.7%), 8 (1.8%), and 6 (1.4%) healthy control subjects had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) organ-specific autoantibody in their sera, respectively. Of 255 TGA/TMA-positive BMS patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 87.8%, 5.1%, and 7.1% of these TGA/TMA-positive BMS patients had normal, lower, and higher serum TSH levels, respectively. Conclusion: Approximately 37.5% of 884 BMS patients have serum GPCA/TGA/TMA positivity. Moreover, 12.3%, 21.6%, and 22.7% of 884 BMS patients have the serum GPCA, TGA, and TMA positivities, respectively. Only 5.1% and 7.1% of TGA/TMA-positive BMS patients have hyperthyroidism and hypothyroidism, respectively. It needs further studies to know whether GPCA-positive BMS patients may finally become as having autoimmune atrophic gastritis.http://www.sciencedirect.com/science/article/pii/S0929664620304095Burning mouth syndromeGastric parietal cell antibodyThyroglobulin antibodyThyroid microsomal antibody |
| spellingShingle | Chun-Pin Chiang Yang-Che Wu Yu-Hsueh Wu Julia Yu-Fong Chang Yi-Ping Wang Andy Sun Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome Journal of the Formosan Medical Association Burning mouth syndrome Gastric parietal cell antibody Thyroglobulin antibody Thyroid microsomal antibody |
| title | Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome |
| title_full | Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome |
| title_fullStr | Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome |
| title_full_unstemmed | Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome |
| title_short | Gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome |
| title_sort | gastric parietal cell and thyroid autoantibodies in patients with burning mouth syndrome |
| topic | Burning mouth syndrome Gastric parietal cell antibody Thyroglobulin antibody Thyroid microsomal antibody |
| url | http://www.sciencedirect.com/science/article/pii/S0929664620304095 |
| work_keys_str_mv | AT chunpinchiang gastricparietalcellandthyroidautoantibodiesinpatientswithburningmouthsyndrome AT yangchewu gastricparietalcellandthyroidautoantibodiesinpatientswithburningmouthsyndrome AT yuhsuehwu gastricparietalcellandthyroidautoantibodiesinpatientswithburningmouthsyndrome AT juliayufongchang gastricparietalcellandthyroidautoantibodiesinpatientswithburningmouthsyndrome AT yipingwang gastricparietalcellandthyroidautoantibodiesinpatientswithburningmouthsyndrome AT andysun gastricparietalcellandthyroidautoantibodiesinpatientswithburningmouthsyndrome |