The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population
Abstract Background Several studies have reported that fat mass and obesity-associated gene (FTO), especially the rs9939609 polymorphism, are associated with obesity and high leptin levels. The free leptin index (FLI) is known to be accurate in determining the function of leptin. The aim of this stu...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-07-01
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| Series: | Egyptian Journal of Medical Human Genetics |
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| Online Access: | https://doi.org/10.1186/s43042-022-00321-w |
| _version_ | 1828760201336979456 |
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| author | Siska Mayasari Lubis Miswar Fattah Jose R. L. Batubara |
| author_facet | Siska Mayasari Lubis Miswar Fattah Jose R. L. Batubara |
| author_sort | Siska Mayasari Lubis |
| collection | DOAJ |
| description | Abstract Background Several studies have reported that fat mass and obesity-associated gene (FTO), especially the rs9939609 polymorphism, are associated with obesity and high leptin levels. The free leptin index (FLI) is known to be accurate in determining the function of leptin. The aim of this study was to determine the association between the rs9939609 variant in the FTO gene and FLI and the risk of obesity among children living in Medan, Indonesia. Methods This case–control study included 212 children aged 6–12 years who were genotyped for variants of the rs9939609 FTO gene. The case group consisted of children with obesity who were < 6 years old, and the control group had a normal body mass index and came from the Bataknese or Chinese ethnicities. Anthropometric measurements were performed. Serum leptin and soluble leptin receptor (sOB-R) levels were measured. Odds ratio and 95% confidence intervals were calculated to determine the risk of having obesity associated with the risk allele. Results In this study, there was no significant association between leptin, soluble leptin receptor, or free leptin index and the rs9939609 FTO gene; however, the risk allele (A) of FTO rs9939609 had a significant association with obesity in Chinese ethnicity subjects (p < 0.05). The AA/AT genotype had an increased risk of FLI 5.889 times compared to the TT genotype. Multivariate analysis showed that the rs9939609 polymorphism in the FTO gene played a role in obesity through the FLI. Conclusion It was concluded that the rs9939609 polymorphism played a significant role in obesity through FLI. Further studies are still needed. |
| first_indexed | 2024-12-11T01:10:16Z |
| format | Article |
| id | doaj.art-dd04ca1317c14819bcfffc999250263b |
| institution | Directory Open Access Journal |
| issn | 2090-2441 |
| language | English |
| last_indexed | 2024-12-11T01:10:16Z |
| publishDate | 2022-07-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Journal of Medical Human Genetics |
| spelling | doaj.art-dd04ca1317c14819bcfffc999250263b2022-12-22T01:26:04ZengSpringerOpenEgyptian Journal of Medical Human Genetics2090-24412022-07-012311710.1186/s43042-022-00321-wThe association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children populationSiska Mayasari Lubis0Miswar Fattah1Jose R. L. Batubara2Pediatric Endocrinology Division, Department of Child Health, Faculty of Medicine, Universitas Sumatera UtaraDepartment of Molecular Biology, Prodia Widyahusada LaboratoryPediatric Endocrinology Division, Department of Child Health, Faculty of Medicine, Universitas IndonesiaAbstract Background Several studies have reported that fat mass and obesity-associated gene (FTO), especially the rs9939609 polymorphism, are associated with obesity and high leptin levels. The free leptin index (FLI) is known to be accurate in determining the function of leptin. The aim of this study was to determine the association between the rs9939609 variant in the FTO gene and FLI and the risk of obesity among children living in Medan, Indonesia. Methods This case–control study included 212 children aged 6–12 years who were genotyped for variants of the rs9939609 FTO gene. The case group consisted of children with obesity who were < 6 years old, and the control group had a normal body mass index and came from the Bataknese or Chinese ethnicities. Anthropometric measurements were performed. Serum leptin and soluble leptin receptor (sOB-R) levels were measured. Odds ratio and 95% confidence intervals were calculated to determine the risk of having obesity associated with the risk allele. Results In this study, there was no significant association between leptin, soluble leptin receptor, or free leptin index and the rs9939609 FTO gene; however, the risk allele (A) of FTO rs9939609 had a significant association with obesity in Chinese ethnicity subjects (p < 0.05). The AA/AT genotype had an increased risk of FLI 5.889 times compared to the TT genotype. Multivariate analysis showed that the rs9939609 polymorphism in the FTO gene played a role in obesity through the FLI. Conclusion It was concluded that the rs9939609 polymorphism played a significant role in obesity through FLI. Further studies are still needed.https://doi.org/10.1186/s43042-022-00321-wPolymorphismrs9939609ObesityFLIFTO |
| spellingShingle | Siska Mayasari Lubis Miswar Fattah Jose R. L. Batubara The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population Egyptian Journal of Medical Human Genetics Polymorphism rs9939609 Obesity FLI FTO |
| title | The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population |
| title_full | The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population |
| title_fullStr | The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population |
| title_full_unstemmed | The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population |
| title_short | The association between variant rs9939609 in the FTO gene with free leptin index and the risk of obesity in the Indonesian children population |
| title_sort | association between variant rs9939609 in the fto gene with free leptin index and the risk of obesity in the indonesian children population |
| topic | Polymorphism rs9939609 Obesity FLI FTO |
| url | https://doi.org/10.1186/s43042-022-00321-w |
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