Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop
Humans constantly learn in the absence of explicit rewards. However, the neurobiological mechanisms supporting this type of internally-guided learning (without explicit feedback) are still unclear. Here, participants who completed a task in which no external reward/feedback was provided, exhibited e...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2016-09-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/17441 |
| _version_ | 1818018601847750656 |
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| author | Pablo Ripollés Josep Marco-Pallarés Helena Alicart Claus Tempelmann Antoni Rodríguez-Fornells Toemme Noesselt |
| author_facet | Pablo Ripollés Josep Marco-Pallarés Helena Alicart Claus Tempelmann Antoni Rodríguez-Fornells Toemme Noesselt |
| author_sort | Pablo Ripollés |
| collection | DOAJ |
| description | Humans constantly learn in the absence of explicit rewards. However, the neurobiological mechanisms supporting this type of internally-guided learning (without explicit feedback) are still unclear. Here, participants who completed a task in which no external reward/feedback was provided, exhibited enhanced fMRI-signals within the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop) when successfully grasping the meaning of new-words. Importantly, new-words that were better remembered showed increased activation and enhanced functional connectivity between the midbrain, hippocampus, and ventral striatum. Moreover, enhanced emotion-related physiological measures and subjective pleasantness ratings during encoding were associated with remembered new-words after 24 hr. Furthermore, increased subjective pleasantness ratings were also related to new-words remembered after seven days. These results suggest that intrinsic—potentially reward-related—signals, triggered by self-monitoring of correct performance, can promote the storage of new information into long-term memory through the activation of the SN/VTA-Hippocampal loop, possibly via dopaminergic modulation of the midbrain. |
| first_indexed | 2024-04-14T07:41:49Z |
| format | Article |
| id | doaj.art-dd05abfdfad14a6685b57a5f9cfd7b60 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:41:49Z |
| publishDate | 2016-09-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-dd05abfdfad14a6685b57a5f9cfd7b602022-12-22T02:05:28ZengeLife Sciences Publications LtdeLife2050-084X2016-09-01510.7554/eLife.17441Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loopPablo Ripollés0Josep Marco-Pallarés1Helena Alicart2Claus Tempelmann3Antoni Rodríguez-Fornells4Toemme Noesselt5https://orcid.org/0000-0002-9611-9713Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona, Spain; Department of Basic Psychology, University of Barcelona, Barcelona, SpainCognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona, Spain; Department of Basic Psychology, University of Barcelona, Barcelona, SpainCognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona, SpainDepartment of Neurology, Otto-von-Guericke University, Magdeburg, GermanyCognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona, Spain; Catalan Institution for Research and Advanced Studies, ICREA, Barcelona, SpainDepartment of Biological Psychology, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany; Center for Behavioral Brain Sciences, Magdeburg, GermanyHumans constantly learn in the absence of explicit rewards. However, the neurobiological mechanisms supporting this type of internally-guided learning (without explicit feedback) are still unclear. Here, participants who completed a task in which no external reward/feedback was provided, exhibited enhanced fMRI-signals within the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop) when successfully grasping the meaning of new-words. Importantly, new-words that were better remembered showed increased activation and enhanced functional connectivity between the midbrain, hippocampus, and ventral striatum. Moreover, enhanced emotion-related physiological measures and subjective pleasantness ratings during encoding were associated with remembered new-words after 24 hr. Furthermore, increased subjective pleasantness ratings were also related to new-words remembered after seven days. These results suggest that intrinsic—potentially reward-related—signals, triggered by self-monitoring of correct performance, can promote the storage of new information into long-term memory through the activation of the SN/VTA-Hippocampal loop, possibly via dopaminergic modulation of the midbrain.https://elifesciences.org/articles/17441SN/VTA-Hippocampal looprewardmemoryfMRIword learningdopamine |
| spellingShingle | Pablo Ripollés Josep Marco-Pallarés Helena Alicart Claus Tempelmann Antoni Rodríguez-Fornells Toemme Noesselt Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop eLife SN/VTA-Hippocampal loop reward memory fMRI word learning dopamine |
| title | Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop |
| title_full | Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop |
| title_fullStr | Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop |
| title_full_unstemmed | Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop |
| title_short | Intrinsic monitoring of learning success facilitates memory encoding via the activation of the SN/VTA-Hippocampal loop |
| title_sort | intrinsic monitoring of learning success facilitates memory encoding via the activation of the sn vta hippocampal loop |
| topic | SN/VTA-Hippocampal loop reward memory fMRI word learning dopamine |
| url | https://elifesciences.org/articles/17441 |
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