Trypanosome spliced leader RNA for diagnosis of acoziborole treatment outcome in gambiense human African trypanosomiasis: A longitudinal follow-up studyResearch in context

Trypanosome spliced leader RNA for diagnosis of acoziborole treatment outcome in gambiense human African trypanosomiasis: A longitudinal follow-up studyResearch in context

Summary: Background: Detection of spliced leader (SL)-RNA allows sensitive diagnosis of gambiense human African trypanosomiasis (HAT). We investigated its diagnostic performance for treatment outcome assessment. Methods: Blood and cerebrospinal fluid (CSF) from a consecutive series of 97 HAT patien...

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Bibliographic Details
Main Authors: Ipos Ngay Lukusa, Nick Van Reet, Dieudonné Mumba Ngoyi, Erick Mwamba Miaka, Justin Masumu, Pati Patient Pyana, Wilfried Mutombo, Digas Ngolo, Vincent Kobo, Felix Akwaso, Médard Ilunga, Lewis Kaninda, Sylvain Mutanda, Dieudonné Mpoyi Muamba, Olaf Valverde Mordt, Antoine Tarral, Sandra Rembry, Philippe Büscher, Veerle Lejon
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:EBioMedicine
Subjects:
Human African trypanosomiasis
Trypanosoma brucei gambiense
Treatment outcome
Relapse
RNA
Diagnosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396422005588

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