GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?
<p>Abstract</p> <p>Background</p> <p>Recent studies revealed that glucokinase regulatory protein (GCKR) variants (rs780094 and rs1260326) are associated with serum triglycerides and plasma glucose levels. Here we analyzed primarily the association of these two variants...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-11-01
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| Series: | Cardiovascular Diabetology |
| Online Access: | http://www.cardiab.com/content/9/1/79 |
| _version_ | 1828971053717651456 |
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| author | Hetyésy Katalin Sümegi Katalin Cseh Judit Sáfrány Enikő Polgár Noémi Csöngei Veronika Fehér Eszter Maász Anita Járomi Luca Kisfali Péter Mohás Márton Wittmann István Melegh Béla |
| author_facet | Hetyésy Katalin Sümegi Katalin Cseh Judit Sáfrány Enikő Polgár Noémi Csöngei Veronika Fehér Eszter Maász Anita Járomi Luca Kisfali Péter Mohás Márton Wittmann István Melegh Béla |
| author_sort | Hetyésy Katalin |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Recent studies revealed that glucokinase regulatory protein (GCKR) variants (rs780094 and rs1260326) are associated with serum triglycerides and plasma glucose levels. Here we analyzed primarily the association of these two variants with the lipid profile and plasma glucose levels in Hungarian subjects with type 2 diabetes mellitus and metabolic syndrome; and also correlated the genotypes with the carotid intima-media thickness records.</p> <p>Methods</p> <p>A total of 321 type 2 diabetic patients, 455 metabolic syndrome patients, and 172 healthy controls were genotyped by PCR-RFLP.</p> <p>Results</p> <p>Both GCKR variants were found to associate with serum triglycerides and with fasting plasma glucose. However, significant association with the development of type 2 diabetes mellitus and metabolic syndrome could not be observed. Analyzing the records of the patients, a positive association of prevalence the GCKR homozygous functional variants and carotid intima-media thickness was found in the metabolic syndrome patients.</p> <p>Conclusions</p> <p>Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations. Besides this positive replication, as a novel feature, our preliminary findings also suggest a cardiovascular risk role of the GCKR minor allele carriage based on the carotid intima-media thickness association.</p> |
| first_indexed | 2024-12-14T13:02:54Z |
| format | Article |
| id | doaj.art-dd066670e4c24bdaa4b268c1c365700e |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-12-14T13:02:54Z |
| publishDate | 2010-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-dd066670e4c24bdaa4b268c1c365700e2022-12-21T23:00:23ZengBMCCardiovascular Diabetology1475-28402010-11-01917910.1186/1475-2840-9-79GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?Hetyésy KatalinSümegi KatalinCseh JuditSáfrány EnikőPolgár NoémiCsöngei VeronikaFehér EszterMaász AnitaJáromi LucaKisfali PéterMohás MártonWittmann IstvánMelegh Béla<p>Abstract</p> <p>Background</p> <p>Recent studies revealed that glucokinase regulatory protein (GCKR) variants (rs780094 and rs1260326) are associated with serum triglycerides and plasma glucose levels. Here we analyzed primarily the association of these two variants with the lipid profile and plasma glucose levels in Hungarian subjects with type 2 diabetes mellitus and metabolic syndrome; and also correlated the genotypes with the carotid intima-media thickness records.</p> <p>Methods</p> <p>A total of 321 type 2 diabetic patients, 455 metabolic syndrome patients, and 172 healthy controls were genotyped by PCR-RFLP.</p> <p>Results</p> <p>Both GCKR variants were found to associate with serum triglycerides and with fasting plasma glucose. However, significant association with the development of type 2 diabetes mellitus and metabolic syndrome could not be observed. Analyzing the records of the patients, a positive association of prevalence the GCKR homozygous functional variants and carotid intima-media thickness was found in the metabolic syndrome patients.</p> <p>Conclusions</p> <p>Our results support that rs780094 and rs1260326 functional variants of the GCKR gene are inversely associated with serum triglycerides and fasting plasma glucose levels, as it was already reported for diabetic and metabolic syndrome patients in some other populations. Besides this positive replication, as a novel feature, our preliminary findings also suggest a cardiovascular risk role of the GCKR minor allele carriage based on the carotid intima-media thickness association.</p>http://www.cardiab.com/content/9/1/79 |
| spellingShingle | Hetyésy Katalin Sümegi Katalin Cseh Judit Sáfrány Enikő Polgár Noémi Csöngei Veronika Fehér Eszter Maász Anita Járomi Luca Kisfali Péter Mohás Márton Wittmann István Melegh Béla GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? Cardiovascular Diabetology |
| title | GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? |
| title_full | GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? |
| title_fullStr | GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? |
| title_full_unstemmed | GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? |
| title_short | GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness? |
| title_sort | gckr gene functional variants in type 2 diabetes and metabolic syndrome do the rare variants associate with increased carotid intima media thickness |
| url | http://www.cardiab.com/content/9/1/79 |
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