Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies
Seventeen new xanthene-1,8-dione derivatives were synthesized and evaluated as cytotoxic agents against the lung carcinoma cell line (A549). Compound 9-(4-(benzyloxy)phenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (4a) showed good cytotoxic effects (34.59 μM) in comparison to cis-platin. Doc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2024-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2024/6612503 |
| _version_ | 1797356500193116160 |
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| author | Ahmad Ebadi Aref Karimi Asrin Bahmani Zahra Najafi Gholamabbas Chehardoli |
| author_facet | Ahmad Ebadi Aref Karimi Asrin Bahmani Zahra Najafi Gholamabbas Chehardoli |
| author_sort | Ahmad Ebadi |
| collection | DOAJ |
| description | Seventeen new xanthene-1,8-dione derivatives were synthesized and evaluated as cytotoxic agents against the lung carcinoma cell line (A549). Compound 9-(4-(benzyloxy)phenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (4a) showed good cytotoxic effects (34.59 μM) in comparison to cis-platin. Docking results showed 4a could interact with DNA as intercalation. Calculated ligand efficiency of compound 4a was more than daunomycin. Based on the results, it can be concluded that compound 4a is a suitable DNA binding agent. |
| first_indexed | 2024-03-08T14:27:34Z |
| format | Article |
| id | doaj.art-dd0734fd586544ada70c88078cd3e6f2 |
| institution | Directory Open Access Journal |
| issn | 2090-9071 |
| language | English |
| last_indexed | 2024-03-08T14:27:34Z |
| publishDate | 2024-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj.art-dd0734fd586544ada70c88078cd3e6f22024-01-13T00:00:00ZengHindawi LimitedJournal of Chemistry2090-90712024-01-01202410.1155/2024/6612503Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico StudiesAhmad Ebadi0Aref Karimi1Asrin Bahmani2Zahra Najafi3Gholamabbas Chehardoli4Department of Medicinal ChemistryDepartment of Medicinal ChemistryDepartment of Medicinal ChemistryDepartment of Medicinal ChemistryDepartment of Medicinal ChemistrySeventeen new xanthene-1,8-dione derivatives were synthesized and evaluated as cytotoxic agents against the lung carcinoma cell line (A549). Compound 9-(4-(benzyloxy)phenyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione (4a) showed good cytotoxic effects (34.59 μM) in comparison to cis-platin. Docking results showed 4a could interact with DNA as intercalation. Calculated ligand efficiency of compound 4a was more than daunomycin. Based on the results, it can be concluded that compound 4a is a suitable DNA binding agent.http://dx.doi.org/10.1155/2024/6612503 |
| spellingShingle | Ahmad Ebadi Aref Karimi Asrin Bahmani Zahra Najafi Gholamabbas Chehardoli Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies Journal of Chemistry |
| title | Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies |
| title_full | Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies |
| title_fullStr | Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies |
| title_full_unstemmed | Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies |
| title_short | Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies |
| title_sort | novel xanthene 1 8 dione derivatives containing the benzylic ether tail as potent cytotoxic agents design synthesis in vitro and in silico studies |
| url | http://dx.doi.org/10.1155/2024/6612503 |
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