Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences
Obstructive sleep apnea (OSA) is a chronic disorder characterized by recurrent episodes of apnea and hypopnea during sleep. It is associated with various cardiovascular and metabolic complications, including type 2 diabetes mellitus (T2DM) and obesity. Many pathways can be responsible for T2DM devel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/1/60 |
| _version_ | 1797438828539019264 |
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| author | Mikołaj Malicki Filip Franciszek Karuga Bartosz Szmyd Marcin Sochal Agata Gabryelska |
| author_facet | Mikołaj Malicki Filip Franciszek Karuga Bartosz Szmyd Marcin Sochal Agata Gabryelska |
| author_sort | Mikołaj Malicki |
| collection | DOAJ |
| description | Obstructive sleep apnea (OSA) is a chronic disorder characterized by recurrent episodes of apnea and hypopnea during sleep. It is associated with various cardiovascular and metabolic complications, including type 2 diabetes mellitus (T2DM) and obesity. Many pathways can be responsible for T2DM development in OSA patients, e.g., those related to HIF-1 and SIRT1 expression. Moreover, epigenetic mechanisms, such as <i>miRNA181a</i> or <i>miRNA199</i>, are postulated to play a pivotal role in this link. It has been proven that OSA increases the occurrence of circadian clock disruption, which is also a risk factor for metabolic disease development. Circadian clock disruption impairs the metabolism of glucose, lipids, and the secretion of bile acids. Therefore, OSA-induced circadian clock disruption may be a potential, complex, underlying pathway involved in developing and exacerbating metabolic diseases among OSA patients. The current paper summarizes the available information pertaining to the relationship between OSA and circadian clock disruption in the context of potential mechanisms leading to metabolic disorders. |
| first_indexed | 2024-03-09T11:43:56Z |
| format | Article |
| id | doaj.art-dd0856bb5c83443984d832212a174e9f |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T11:43:56Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-dd0856bb5c83443984d832212a174e9f2023-11-30T23:28:27ZengMDPI AGMetabolites2218-19892022-12-011316010.3390/metabo13010060Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic ConsequencesMikołaj Malicki0Filip Franciszek Karuga1Bartosz Szmyd2Marcin Sochal3Agata Gabryelska4Department of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Pediatrics, Oncology, and Hematology, Medical University of Lodz, 91-738 Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, PolandDepartment of Sleep Medicine and Metabolic Disorders, Medical University of Lodz, 92-215 Lodz, PolandObstructive sleep apnea (OSA) is a chronic disorder characterized by recurrent episodes of apnea and hypopnea during sleep. It is associated with various cardiovascular and metabolic complications, including type 2 diabetes mellitus (T2DM) and obesity. Many pathways can be responsible for T2DM development in OSA patients, e.g., those related to HIF-1 and SIRT1 expression. Moreover, epigenetic mechanisms, such as <i>miRNA181a</i> or <i>miRNA199</i>, are postulated to play a pivotal role in this link. It has been proven that OSA increases the occurrence of circadian clock disruption, which is also a risk factor for metabolic disease development. Circadian clock disruption impairs the metabolism of glucose, lipids, and the secretion of bile acids. Therefore, OSA-induced circadian clock disruption may be a potential, complex, underlying pathway involved in developing and exacerbating metabolic diseases among OSA patients. The current paper summarizes the available information pertaining to the relationship between OSA and circadian clock disruption in the context of potential mechanisms leading to metabolic disorders.https://www.mdpi.com/2218-1989/13/1/60OSAcircadian disruptiondiabetes mellitusobesitymetabolic complicationsmicroRNA |
| spellingShingle | Mikołaj Malicki Filip Franciszek Karuga Bartosz Szmyd Marcin Sochal Agata Gabryelska Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences Metabolites OSA circadian disruption diabetes mellitus obesity metabolic complications microRNA |
| title | Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences |
| title_full | Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences |
| title_fullStr | Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences |
| title_full_unstemmed | Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences |
| title_short | Obstructive Sleep Apnea, Circadian Clock Disruption, and Metabolic Consequences |
| title_sort | obstructive sleep apnea circadian clock disruption and metabolic consequences |
| topic | OSA circadian disruption diabetes mellitus obesity metabolic complications microRNA |
| url | https://www.mdpi.com/2218-1989/13/1/60 |
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