Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma
Abstract Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to massive bleeding and high recurrence. In particular, combination therapy for HCC...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-022-01559-7 |
| _version_ | 1818000758778363904 |
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| author | Sheng Chen Yonghong Song Xu Yan Liang Dong Yunjun Xu Shouhu Xuan Quan Shu Baoqiang Cao Jinlong Hu Hanye Xing Wenshu Wu Zhengbao Zha Yang Lu |
| author_facet | Sheng Chen Yonghong Song Xu Yan Liang Dong Yunjun Xu Shouhu Xuan Quan Shu Baoqiang Cao Jinlong Hu Hanye Xing Wenshu Wu Zhengbao Zha Yang Lu |
| author_sort | Sheng Chen |
| collection | DOAJ |
| description | Abstract Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to massive bleeding and high recurrence. In particular, combination therapy for HCC has been highly recommended in clinical practice, including surgical resection, interventional therapy, ablation therapy and chemotherapy. Herein, an injectable magnetic colloidal gel (MCG) was developed by controllable electrostatic attraction between clinically available magnetic montmorillonites and amphoteric gelatin nanoparticles. The optimized MCG exhibited an effective magnetic heating effect, remarkable rheological properties, and high gel network stability, realizing the synergistic treatment of postoperative HCC by stimuli-responsive drug delivery, hemostasis and magnetic hyperthermia. Furthermore, a minimal invasive MCG-induced interventional magnetic hyperthermia therapy (MHT) under ultrasound guidance was realized on hepatic tumor rabbits, providing an alternative therapeutics to treat the postoperative recurrence. Overall, MCG is a clinically available injectable formulation for adjuvant therapy after HCC surgical resection. |
| first_indexed | 2024-04-14T03:25:49Z |
| format | Article |
| id | doaj.art-dd08775dea164246afdaf129d28f2a9d |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-14T03:25:49Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-dd08775dea164246afdaf129d28f2a9d2022-12-22T02:15:11ZengBMCJournal of Nanobiotechnology1477-31552022-08-0120111510.1186/s12951-022-01559-7Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinomaSheng Chen0Yonghong Song1Xu Yan2Liang Dong3Yunjun Xu4Shouhu Xuan5Quan Shu6Baoqiang Cao7Jinlong Hu8Hanye Xing9Wenshu Wu10Zhengbao Zha11Yang Lu12Anhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of TechnologyAnhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of TechnologyAnhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of TechnologyDivision of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of ChinaDivision of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of ChinaDivision of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of ChinaDivision of Nanomaterials & Chemistry, Department of Modern Mechanics, Department of Radiology, Hefei National Laboratory for Physical Sciences at the Microscale, The First Affiliated Hospital of University of Science and Technology of China, University of Science and Technology of ChinaDepartment of General Surgery, Department of Ultrasonics, Department of Interventional Radiology, Anhui No. 2 Provincial People’s HospitalDepartment of General Surgery, Department of Ultrasonics, Department of Interventional Radiology, Anhui No. 2 Provincial People’s HospitalAnhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of TechnologyAnhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of TechnologyAnhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of TechnologyAnhui Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of TechnologyAbstract Bioactive materials have been extensively developed for the adjuvant therapy of cancer. However, few materials can meet the requirements for the postoperative resection of hepatocellular carcinoma (HCC) due to massive bleeding and high recurrence. In particular, combination therapy for HCC has been highly recommended in clinical practice, including surgical resection, interventional therapy, ablation therapy and chemotherapy. Herein, an injectable magnetic colloidal gel (MCG) was developed by controllable electrostatic attraction between clinically available magnetic montmorillonites and amphoteric gelatin nanoparticles. The optimized MCG exhibited an effective magnetic heating effect, remarkable rheological properties, and high gel network stability, realizing the synergistic treatment of postoperative HCC by stimuli-responsive drug delivery, hemostasis and magnetic hyperthermia. Furthermore, a minimal invasive MCG-induced interventional magnetic hyperthermia therapy (MHT) under ultrasound guidance was realized on hepatic tumor rabbits, providing an alternative therapeutics to treat the postoperative recurrence. Overall, MCG is a clinically available injectable formulation for adjuvant therapy after HCC surgical resection.https://doi.org/10.1186/s12951-022-01559-7Colloidal gelMagnetic hyperthermiaHepatocellular carcinomaPostoperative therapyHemostasis |
| spellingShingle | Sheng Chen Yonghong Song Xu Yan Liang Dong Yunjun Xu Shouhu Xuan Quan Shu Baoqiang Cao Jinlong Hu Hanye Xing Wenshu Wu Zhengbao Zha Yang Lu Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma Journal of Nanobiotechnology Colloidal gel Magnetic hyperthermia Hepatocellular carcinoma Postoperative therapy Hemostasis |
| title | Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma |
| title_full | Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma |
| title_fullStr | Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma |
| title_full_unstemmed | Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma |
| title_short | Injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma |
| title_sort | injectable magnetic montmorillonite colloidal gel for the postoperative treatment of hepatocellular carcinoma |
| topic | Colloidal gel Magnetic hyperthermia Hepatocellular carcinoma Postoperative therapy Hemostasis |
| url | https://doi.org/10.1186/s12951-022-01559-7 |
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