A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance
The discovery of the first ATP-binding cassette (ABC) transporter, whose overexpression in cancer cells is responsible for exporting anticancer drugs out of tumor cells, initiated enormous efforts to overcome tumor cell multidrug resistance (MDR) by inhibition of ABC-transporter. Because of its many...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/2/495 |
| _version_ | 1827623028167540736 |
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| author | Jiahui Huang Gerhard F. Ecker |
| author_facet | Jiahui Huang Gerhard F. Ecker |
| author_sort | Jiahui Huang |
| collection | DOAJ |
| description | The discovery of the first ATP-binding cassette (ABC) transporter, whose overexpression in cancer cells is responsible for exporting anticancer drugs out of tumor cells, initiated enormous efforts to overcome tumor cell multidrug resistance (MDR) by inhibition of ABC-transporter. Because of its many physiological functions, diverse studies have been conducted on the mechanism, function and regulation of this important group of transmembrane transport proteins. In this review, we will focus on the structural aspects of this transporter superfamily. Since the resolution revolution of electron microscope, experimentally solved structures increased rapidly. A summary of the structures available and an overview of recent structure-based studies are provided. More specifically, the artificial intelligence (AI)-based predictions from AlphaFold-2 will be discussed. |
| first_indexed | 2024-03-09T11:37:35Z |
| format | Article |
| id | doaj.art-dd08fa78325e429ca4dea7c5e26f28e0 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T11:37:35Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-dd08fa78325e429ca4dea7c5e26f28e02023-11-30T23:40:40ZengMDPI AGMolecules1420-30492023-01-0128249510.3390/molecules28020495A Structure-Based View on ABC-Transporter Linked to Multidrug ResistanceJiahui Huang0Gerhard F. Ecker1Department of Pharmaceutical Sciences, University of Vienna, 1140 Vienna, AustriaDepartment of Pharmaceutical Sciences, University of Vienna, 1140 Vienna, AustriaThe discovery of the first ATP-binding cassette (ABC) transporter, whose overexpression in cancer cells is responsible for exporting anticancer drugs out of tumor cells, initiated enormous efforts to overcome tumor cell multidrug resistance (MDR) by inhibition of ABC-transporter. Because of its many physiological functions, diverse studies have been conducted on the mechanism, function and regulation of this important group of transmembrane transport proteins. In this review, we will focus on the structural aspects of this transporter superfamily. Since the resolution revolution of electron microscope, experimentally solved structures increased rapidly. A summary of the structures available and an overview of recent structure-based studies are provided. More specifically, the artificial intelligence (AI)-based predictions from AlphaFold-2 will be discussed.https://www.mdpi.com/1420-3049/28/2/495structure-based studiesABC transportermultidrug resistance (MDR)cancer therapy |
| spellingShingle | Jiahui Huang Gerhard F. Ecker A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance Molecules structure-based studies ABC transporter multidrug resistance (MDR) cancer therapy |
| title | A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance |
| title_full | A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance |
| title_fullStr | A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance |
| title_full_unstemmed | A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance |
| title_short | A Structure-Based View on ABC-Transporter Linked to Multidrug Resistance |
| title_sort | structure based view on abc transporter linked to multidrug resistance |
| topic | structure-based studies ABC transporter multidrug resistance (MDR) cancer therapy |
| url | https://www.mdpi.com/1420-3049/28/2/495 |
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