CT Perfusion Dynamics of Intracranial Tuberculomas
Aims: To study perfusion characteristics of intracranial tuberculomas and analyze changes with anti tubercular treatment. Materials and Methods: Nineteen patients of histologically proven intracranial tuberculomas were included in the study of which 9 were not on antitubercular treatment and ten...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5880/11587_CE(RA1)_F(T)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Aims: To study perfusion characteristics of intracranial tuberculomas and analyze changes with anti tubercular treatment.
Materials and Methods: Nineteen patients of histologically
proven intracranial tuberculomas were included in the study of
which 9 were not on antitubercular treatment and ten were on
antitubercular treatment (6 patients on treatment for less than 2
months and 4 were more than 6 months). All patients underwent
CT perfusion (CTP) and CTP parameters like rCBV and rCBF
were obtained from entire lesion, center and capsule of lesions
and compared.
Results: CTP parameters like rCBF and rCBV were significantly
low in all the three ROIs in the group not on treatment compared to
that of on treatment ; rCBF and rCBV of entire lesion (p=0.018 and
p=0.005 respectively), capsule (p=0.045 and p=0.010 respectively)
and center of the lesion (p=0.020 and p=0.009) respectively).
Tuberculomas on antitubercular treatment of more than six
months showed reduced rCBF and rCBV in entire lesion (p=0.01
& p=0.01 respectively), capsule (p=0.04 & p=0.03 respectively)
and center (p=0.08 & p=0.05 respectively) compared to those
on treatment for less than two months. Similarly tuberculomas
on treatment for six months did not show significant difference
in rCBF and rCBV compared to tuberculomas who were not
on treatment. Tuberculomas on treatment for less than two
months showed statistically increased rCBF and rCBV in entire
lesion (p=0.01 & p=0.04 respectively), capsule (p=0.03 & p=0.01
respectively) and center (p= 0.03 &=0.01) compared to those not
on treatment.
Conclusion: Intracranial tuberculomas not on treatment and
those on treatment for around six months show low perfusion and
tuberculomas on treatment for less than two months show high
perfusion. These findings suggest that serial perfusion profiles of
tuberculomas on treatment could possibly be seen as surrogate
markers of response to treatment. |
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| ISSN: | 2249-782X 0973-709X |