An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques
Atherosclerosis progression is linked to inflammatory processes in the blood vessel wall. Here, the authors show that, with the progression of atherosclerosis, the resolution of inflammation is impaired as the result of an imbalance between specialized pro-resolving lipid mediators and leukotrienes.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms12859 |
| _version_ | 1818342663841120256 |
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| author | Gabrielle Fredman Jason Hellmann Jonathan D. Proto George Kuriakose Romain A. Colas Bernhard Dorweiler E. Sander Connolly Robert Solomon David M. Jones Eric J. Heyer Matthew Spite Ira Tabas |
| author_facet | Gabrielle Fredman Jason Hellmann Jonathan D. Proto George Kuriakose Romain A. Colas Bernhard Dorweiler E. Sander Connolly Robert Solomon David M. Jones Eric J. Heyer Matthew Spite Ira Tabas |
| author_sort | Gabrielle Fredman |
| collection | DOAJ |
| description | Atherosclerosis progression is linked to inflammatory processes in the blood vessel wall. Here, the authors show that, with the progression of atherosclerosis, the resolution of inflammation is impaired as the result of an imbalance between specialized pro-resolving lipid mediators and leukotrienes. |
| first_indexed | 2024-12-13T16:18:16Z |
| format | Article |
| id | doaj.art-dd0a0542340e491da02734ce00925f06 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:18:16Z |
| publishDate | 2016-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dd0a0542340e491da02734ce00925f062022-12-21T23:38:48ZengNature PortfolioNature Communications2041-17232016-09-017111110.1038/ncomms12859An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaquesGabrielle Fredman0Jason Hellmann1Jonathan D. Proto2George Kuriakose3Romain A. Colas4Bernhard Dorweiler5E. Sander Connolly6Robert Solomon7David M. Jones8Eric J. Heyer9Matthew Spite10Ira Tabas11Department of Anesthesiology, Departments of Medicine, Perioperative and Pain Medicine, Pathology & Cell Biology, and Physiology, Columbia University Medical CenterDepartment of Anesthesiology, Perioperative and Pain Medicine, The Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Anesthesiology, Departments of Medicine, Perioperative and Pain Medicine, Pathology & Cell Biology, and Physiology, Columbia University Medical CenterDepartment of Anesthesiology, Departments of Medicine, Perioperative and Pain Medicine, Pathology & Cell Biology, and Physiology, Columbia University Medical CenterDepartment of Anesthesiology, Perioperative and Pain Medicine, The Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical SchoolDivision of Vascular Surgery, Department of Cardiothoracic and Vascular Surgery, University Medical Center of the Johannes Gutenberg UniversityDepartment of Neurosurgery, Columbia University Medical CenterDepartment of Neurosurgery, Columbia University Medical CenterThe Department of Pathology, Albany Medical CollegeDepartment of Anesthesiology, Columbia University Medical CenterDepartment of Anesthesiology, Perioperative and Pain Medicine, The Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital and Harvard Medical SchoolDepartment of Anesthesiology, Departments of Medicine, Perioperative and Pain Medicine, Pathology & Cell Biology, and Physiology, Columbia University Medical CenterAtherosclerosis progression is linked to inflammatory processes in the blood vessel wall. Here, the authors show that, with the progression of atherosclerosis, the resolution of inflammation is impaired as the result of an imbalance between specialized pro-resolving lipid mediators and leukotrienes.https://doi.org/10.1038/ncomms12859 |
| spellingShingle | Gabrielle Fredman Jason Hellmann Jonathan D. Proto George Kuriakose Romain A. Colas Bernhard Dorweiler E. Sander Connolly Robert Solomon David M. Jones Eric J. Heyer Matthew Spite Ira Tabas An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques Nature Communications |
| title | An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques |
| title_full | An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques |
| title_fullStr | An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques |
| title_full_unstemmed | An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques |
| title_short | An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques |
| title_sort | imbalance between specialized pro resolving lipid mediators and pro inflammatory leukotrienes promotes instability of atherosclerotic plaques |
| url | https://doi.org/10.1038/ncomms12859 |
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