Effect of TAAR1/5-HT1A agonist SEP-363856 on REM sleep in humans

Effect of TAAR1/5-HT1A agonist SEP-363856 on REM sleep in humans

Abstract SEP-363856 is a trace amine-associated receptor 1 (TAAR1) and 5-hydroxytryptamine type 1A (5-HT1A) agonist, currently in Phase 3 clinical trials for the treatment of schizophrenia. Although SEP-363856 activates TAAR1 and 5-HT1A receptors in vitro, an accessible marker of time- and concentra...

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Bibliographic Details
Main Authors:	Seth C. Hopkins, Nina Dedic, Kenneth S. Koblan
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-04-01
Series:	Translational Psychiatry
Online Access:	https://doi.org/10.1038/s41398-021-01331-9

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