Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal
In this paper, we developed a novel strategy of preparing doxorubicin (DOX) nanocrystal (NC) exerting spherical particles with a diameter of 102 nm, which experienced following coating of chondroitin sulphate derivative (CSOA) shell via electrostatic and hydrophobic interactions. Such multifunctiona...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-01-01
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| Series: | Artificial Cells, Nanomedicine, and Biotechnology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21691401.2020.1813741 |
| _version_ | 1827181494165045248 |
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| author | Yan Liang Xiaoheng Fu Chen Du Haoran Xia Yusi Lai Yong Sun |
| author_facet | Yan Liang Xiaoheng Fu Chen Du Haoran Xia Yusi Lai Yong Sun |
| author_sort | Yan Liang |
| collection | DOAJ |
| description | In this paper, we developed a novel strategy of preparing doxorubicin (DOX) nanocrystal (NC) exerting spherical particles with a diameter of 102 nm, which experienced following coating of chondroitin sulphate derivative (CSOA) shell via electrostatic and hydrophobic interactions. Such multifunctional outerwear resulted in drug nanocapsules with high drug loading content up to 70% and high colloidal stability under physiological conditions. It exhibited accelerated drug release behaviour when dispersing in hyaluronidase (HAase) containing medium or incubated with cancer cells. CSOA/NCs were effectively taken up by cancer cells via CD44 receptor-mediated endocytosis, but were rarely internalised into normal fibroblasts. With the comparison of typical drug-loaded micelles system (DOX/PEG-PCL), CSOA/NCs showed greater inhibition to cancer cells due to the targeted and sensitive drug delivery. |
| first_indexed | 2024-03-13T01:41:10Z |
| format | Article |
| id | doaj.art-dd11e418a4af4a078d54c86dbb595acf |
| institution | Directory Open Access Journal |
| issn | 2169-1401 2169-141X |
| language | English |
| last_indexed | 2025-03-21T05:47:42Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Artificial Cells, Nanomedicine, and Biotechnology |
| spelling | doaj.art-dd11e418a4af4a078d54c86dbb595acf2024-07-23T18:44:30ZengTaylor & Francis GroupArtificial Cells, Nanomedicine, and Biotechnology2169-14012169-141X2020-01-014811114112410.1080/21691401.2020.1813741Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystalYan Liang0Xiaoheng Fu1Chen Du2Haoran Xia3Yusi Lai4Yong Sun5Department of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, ChinaDepartment of Clinical laboratory, No.971 Hospital of the People’s Liberation Army Navy, Qingdao, ChinaDepartment of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, ChinaDepartment of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, ChinaDepartment of Marketing, Sichuan Kelun Pharmaceutical Co., Ltd, Chengdu, ChinaDepartment of Pharmaceutics, School of Pharmacy, Qingdao University, Qingdao, ChinaIn this paper, we developed a novel strategy of preparing doxorubicin (DOX) nanocrystal (NC) exerting spherical particles with a diameter of 102 nm, which experienced following coating of chondroitin sulphate derivative (CSOA) shell via electrostatic and hydrophobic interactions. Such multifunctional outerwear resulted in drug nanocapsules with high drug loading content up to 70% and high colloidal stability under physiological conditions. It exhibited accelerated drug release behaviour when dispersing in hyaluronidase (HAase) containing medium or incubated with cancer cells. CSOA/NCs were effectively taken up by cancer cells via CD44 receptor-mediated endocytosis, but were rarely internalised into normal fibroblasts. With the comparison of typical drug-loaded micelles system (DOX/PEG-PCL), CSOA/NCs showed greater inhibition to cancer cells due to the targeted and sensitive drug delivery.https://www.tandfonline.com/doi/10.1080/21691401.2020.1813741Doxorubicin nanocrystalchondroitin sulphatetargetdrug delivery |
| spellingShingle | Yan Liang Xiaoheng Fu Chen Du Haoran Xia Yusi Lai Yong Sun Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal Artificial Cells, Nanomedicine, and Biotechnology Doxorubicin nanocrystal chondroitin sulphate target drug delivery |
| title | Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal |
| title_full | Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal |
| title_fullStr | Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal |
| title_full_unstemmed | Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal |
| title_short | Enzyme/pH-triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal |
| title_sort | enzyme ph triggered anticancer drug delivery of chondroitin sulfate modified doxorubicin nanocrystal |
| topic | Doxorubicin nanocrystal chondroitin sulphate target drug delivery |
| url | https://www.tandfonline.com/doi/10.1080/21691401.2020.1813741 |
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