The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer
Signet-ring cell carcinoma (SRC) in advanced gastric cancer (GC) is often associated with more invasiveness and a worse prognosis than other cell types. The genetic alterations associated with gastric carcinogenesis in SRC are still unclear. In this study, 441 GC patients receiving curative surgery...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/8/2318 |
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| author | Kuo-Hung Huang Ming-Huang Chen Wen-Liang Fang Chien-Hsing Lin Yee Chao Su-Shun Lo Anna Fen-Yau Li Chew-Wun Wu Yi-Ming Shyr |
| author_facet | Kuo-Hung Huang Ming-Huang Chen Wen-Liang Fang Chien-Hsing Lin Yee Chao Su-Shun Lo Anna Fen-Yau Li Chew-Wun Wu Yi-Ming Shyr |
| author_sort | Kuo-Hung Huang |
| collection | DOAJ |
| description | Signet-ring cell carcinoma (SRC) in advanced gastric cancer (GC) is often associated with more invasiveness and a worse prognosis than other cell types. The genetic alterations associated with gastric carcinogenesis in SRC are still unclear. In this study, 441 GC patients receiving curative surgery for GC between 2005 and 2013 were enrolled. The clinicopathological characteristics and genetic alterations of GC patients with and without SRC were compared. Among the 441 GC patients, 181 had SRC. For early GC, patients with SRC had more tumors located in the middle and lower stomach, more infiltrating tumors and better overall survival (OS) rates than those without SRC. For advanced GC, patients with SRC had more scirrhous type tumors, more <i>PIK3CA</i> amplifications, fewer microsatellite instability-high (MSI-H) tumors, more peritoneal recurrences and worse 5-year OS rates than those without SRC. For advanced GC with SRC, patients with peritoneal recurrence tended to have <i>PD-L1</i> expression. For advanced GC without SRC, patients with liver metastasis tended to have <i>PD-L1</i> expression, <i>PI3K/AKT</i> pathway mutations, <i>TP53</i> mutations and MSI-H tumors. For advanced GC, <i>PD-L1</i> expression was associated with peritoneal recurrence in SRC tumors, while non-SRC tumors with liver metastasis were likely to have <i>PI3K/AKT</i> pathway mutations, <i>TP53</i> mutations and <i>PD-L1</i> expression; immunotherapy and targeted therapy may be beneficial for these patients. |
| first_indexed | 2024-03-10T17:18:42Z |
| format | Article |
| id | doaj.art-dd11ecc227a94a5b9927c5b57ec97894 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T17:18:42Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-dd11ecc227a94a5b9927c5b57ec978942023-11-20T10:26:04ZengMDPI AGCancers2072-66942020-08-01128231810.3390/cancers12082318The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric CancerKuo-Hung Huang0Ming-Huang Chen1Wen-Liang Fang2Chien-Hsing Lin3Yee Chao4Su-Shun Lo5Anna Fen-Yau Li6Chew-Wun Wu7Yi-Ming Shyr8Division of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, TaiwanCenter of Immuno-Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei 11217, TaiwanDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, TaiwanGenome Research Center, National Yang-Ming University, Taipei 11221, TaiwanSchool of Medicine, National Yang-Ming University, Taipei 11221, TaiwanSchool of Medicine, National Yang-Ming University, Taipei 11221, TaiwanSchool of Medicine, National Yang-Ming University, Taipei 11221, TaiwanDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, TaiwanDivision of General Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei 11217, TaiwanSignet-ring cell carcinoma (SRC) in advanced gastric cancer (GC) is often associated with more invasiveness and a worse prognosis than other cell types. The genetic alterations associated with gastric carcinogenesis in SRC are still unclear. In this study, 441 GC patients receiving curative surgery for GC between 2005 and 2013 were enrolled. The clinicopathological characteristics and genetic alterations of GC patients with and without SRC were compared. Among the 441 GC patients, 181 had SRC. For early GC, patients with SRC had more tumors located in the middle and lower stomach, more infiltrating tumors and better overall survival (OS) rates than those without SRC. For advanced GC, patients with SRC had more scirrhous type tumors, more <i>PIK3CA</i> amplifications, fewer microsatellite instability-high (MSI-H) tumors, more peritoneal recurrences and worse 5-year OS rates than those without SRC. For advanced GC with SRC, patients with peritoneal recurrence tended to have <i>PD-L1</i> expression. For advanced GC without SRC, patients with liver metastasis tended to have <i>PD-L1</i> expression, <i>PI3K/AKT</i> pathway mutations, <i>TP53</i> mutations and MSI-H tumors. For advanced GC, <i>PD-L1</i> expression was associated with peritoneal recurrence in SRC tumors, while non-SRC tumors with liver metastasis were likely to have <i>PI3K/AKT</i> pathway mutations, <i>TP53</i> mutations and <i>PD-L1</i> expression; immunotherapy and targeted therapy may be beneficial for these patients.https://www.mdpi.com/2072-6694/12/8/2318signet-ring cellgenetic alterationsadvanced GC<i>PD-L1</i>recurrence patternprognostic factor review |
| spellingShingle | Kuo-Hung Huang Ming-Huang Chen Wen-Liang Fang Chien-Hsing Lin Yee Chao Su-Shun Lo Anna Fen-Yau Li Chew-Wun Wu Yi-Ming Shyr The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer Cancers signet-ring cell genetic alterations advanced GC <i>PD-L1</i> recurrence pattern prognostic factor review |
| title | The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer |
| title_full | The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer |
| title_fullStr | The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer |
| title_full_unstemmed | The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer |
| title_short | The Clinicopathological Characteristics And Genetic Alterations of Signet-ring Cell Carcinoma in Gastric Cancer |
| title_sort | clinicopathological characteristics and genetic alterations of signet ring cell carcinoma in gastric cancer |
| topic | signet-ring cell genetic alterations advanced GC <i>PD-L1</i> recurrence pattern prognostic factor review |
| url | https://www.mdpi.com/2072-6694/12/8/2318 |
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