Reciprocal regulation between alternative splicing and the DNA damage response
Abstract Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternati...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Genética
2020-03-01
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| Series: | Genetics and Molecular Biology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200310&tlng=en |
| _version_ | 1798019385466552320 |
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| author | Adrian E. Cambindo Botto Juan C. Muñoz Luciana E. Giono Nicolás Nieto-Moreno Carmen Cuenca Alberto R. Kornblihtt Manuel J. Muñoz |
| author_facet | Adrian E. Cambindo Botto Juan C. Muñoz Luciana E. Giono Nicolás Nieto-Moreno Carmen Cuenca Alberto R. Kornblihtt Manuel J. Muñoz |
| author_sort | Adrian E. Cambindo Botto |
| collection | DOAJ |
| description | Abstract Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternative isoforms) of their transcriptome. Since 95% of the human coding genome is subjected to alternative splicing regulation, it is expected that many cellular pathways are modulated by alternative splicing, as is the case for the DNA damage response. Moreover, recent evidence demonstrates that upon a genotoxic insult, classical DNA damage response kinases such as ATM, ATR and DNA-PK orchestrate the gene expression response therefore modulating alternative splicing which, in a reciprocal way, shapes the response to a damaging agent. |
| first_indexed | 2024-04-11T16:39:51Z |
| format | Article |
| id | doaj.art-dd12ae2b7d9149b3bcdbfd8d03dc74e9 |
| institution | Directory Open Access Journal |
| issn | 1678-4685 |
| language | English |
| last_indexed | 2024-04-11T16:39:51Z |
| publishDate | 2020-03-01 |
| publisher | Sociedade Brasileira de Genética |
| record_format | Article |
| series | Genetics and Molecular Biology |
| spelling | doaj.art-dd12ae2b7d9149b3bcdbfd8d03dc74e92022-12-22T04:13:42ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-46852020-03-01431 suppl 110.1590/1678-4685-gmb-2019-0111Reciprocal regulation between alternative splicing and the DNA damage responseAdrian E. Cambindo BottoJuan C. MuñozLuciana E. GionoNicolás Nieto-MorenoCarmen CuencaAlberto R. KornblihttManuel J. Muñozhttps://orcid.org/0000-0002-1152-5449Abstract Splicing, the process that catalyzes intron removal and flanking exon ligation, can occur in different ways (alternative splicing) in immature RNAs transcribed from a single gene. In order to adapt to a particular context, cells modulate not only the quantity but also the quality (alternative isoforms) of their transcriptome. Since 95% of the human coding genome is subjected to alternative splicing regulation, it is expected that many cellular pathways are modulated by alternative splicing, as is the case for the DNA damage response. Moreover, recent evidence demonstrates that upon a genotoxic insult, classical DNA damage response kinases such as ATM, ATR and DNA-PK orchestrate the gene expression response therefore modulating alternative splicing which, in a reciprocal way, shapes the response to a damaging agent.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200310&tlng=enDNA damagealternative splicingATRATMDNA-PK |
| spellingShingle | Adrian E. Cambindo Botto Juan C. Muñoz Luciana E. Giono Nicolás Nieto-Moreno Carmen Cuenca Alberto R. Kornblihtt Manuel J. Muñoz Reciprocal regulation between alternative splicing and the DNA damage response Genetics and Molecular Biology DNA damage alternative splicing ATR ATM DNA-PK |
| title | Reciprocal regulation between alternative splicing and the DNA damage response |
| title_full | Reciprocal regulation between alternative splicing and the DNA damage response |
| title_fullStr | Reciprocal regulation between alternative splicing and the DNA damage response |
| title_full_unstemmed | Reciprocal regulation between alternative splicing and the DNA damage response |
| title_short | Reciprocal regulation between alternative splicing and the DNA damage response |
| title_sort | reciprocal regulation between alternative splicing and the dna damage response |
| topic | DNA damage alternative splicing ATR ATM DNA-PK |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000200310&tlng=en |
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