TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC

TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC

Abstract TOPK/PBK (T-LAK Cell-Originated Protein Kinase) is a serine/threonine kinase that is highly expressed in a variety of human tumors and is associated with poor prognosis in many types of human malignancies. Its activation mechanism is not yet fully understood. A bidirectional signal transduc...

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Bibliographic Details
Main Authors: Huimin Sun, Jianzhong Zheng, Juanjuan Xiao, Juntao Yue, Zhiyuan Shi, Zuodong Xuan, Chen Chen, Yue Zhao, Wenbin Tang, Shaopei Ye, Jinxin Li, Qiumin Deng, Lei Zhang, Feng Zhu, Chen Shao
Format: Article
Language:English
Published: Nature Publishing Group 2022-05-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-04909-3

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