Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis
Toxoplasma gondii has been suggested as an important opportunistic pathogen in immunocompromised patients. We conducted a global meta-analysis to assess the prevalence and odds ratios (ORs) of T. gondii infection in immunocompromised individuals. Electronic databases were reviewed for T. gondii infe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-03-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fmicb.2017.00389/full |
| _version_ | 1811312664139268096 |
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| author | Ze-Dong Wang Ze-Dong Wang Ze-Dong Wang Huan-Huan Liu Zhan-Xi Ma Hong-Yu Ma Zhong-Yu Li Zhi-Bin Yang Xing-Quan Zhu Bin Xu Feng Wei Quan Liu Quan Liu |
| author_facet | Ze-Dong Wang Ze-Dong Wang Ze-Dong Wang Huan-Huan Liu Zhan-Xi Ma Hong-Yu Ma Zhong-Yu Li Zhi-Bin Yang Xing-Quan Zhu Bin Xu Feng Wei Quan Liu Quan Liu |
| author_sort | Ze-Dong Wang |
| collection | DOAJ |
| description | Toxoplasma gondii has been suggested as an important opportunistic pathogen in immunocompromised patients. We conducted a global meta-analysis to assess the prevalence and odds ratios (ORs) of T. gondii infection in immunocompromised individuals. Electronic databases were reviewed for T. gondii infection in HIV/AIDS patients, cancer patients, and transplant recipients, and meta-analyses were conducted to calculate overall estimated prevalence and ORs using random or fixed-effects models. Totally, 72 eligible studies were included. The estimated pooled prevalence of T. gondii infection in immunocompromised patients and the control was 35.9 and 24.7% (p < 0.001), with an OR of 2.24, i.e., 42.1 and 32.0% for HIV/AIDS patients and the control (p < 0.05), 26.0 and 12.1% for cancer patients and the control (p < 0.001), and 42.1 and 34.5% for transplant recipients and the control (p > 0.05), whose estimated pooled ORs were 1.92 (95% CI, 1.44–2.55), 2.89 (95% CI, 2.36–3.55), and 1.51 (95% CI, 1.16–1.95), respectively. This study is the first to demonstrate that the immunocompromised patients are associated with higher odds of T. gondii infection, and appropriate prevention and control measures are highly recommended for these susceptible populations. |
| first_indexed | 2024-04-13T10:39:42Z |
| format | Article |
| id | doaj.art-dd15c188c55b40b482eb5a4e21808e76 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-04-13T10:39:42Z |
| publishDate | 2017-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-dd15c188c55b40b482eb5a4e21808e762022-12-22T02:49:57ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2017-03-01810.3389/fmicb.2017.00389238621Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-AnalysisZe-Dong Wang0Ze-Dong Wang1Ze-Dong Wang2Huan-Huan Liu3Zhan-Xi Ma4Hong-Yu Ma5Zhong-Yu Li6Zhi-Bin Yang7Xing-Quan Zhu8Bin Xu9Feng Wei10Quan Liu11Quan Liu12College of Life Science, Jilin Agricultural UniversityChangchun, ChinaState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural SciencesLanzhou, ChinaKey Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Institute, Academy of Military Medical SciencesChangchun, ChinaKey Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Institute, Academy of Military Medical SciencesChangchun, ChinaDepartment of Emergency Medicine, Inner Mongolia General Forestry HospitalYakeshi, ChinaKey Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Institute, Academy of Military Medical SciencesChangchun, ChinaKey Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Institute, Academy of Military Medical SciencesChangchun, ChinaMedical Library of the Chinese people's Liberation ArmyBeijing, ChinaState Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural SciencesLanzhou, ChinaCenter for Prevention and Control of Animal Diseases of Banan District in ChongqingChongqing, ChinaCollege of Life Science, Jilin Agricultural UniversityChangchun, ChinaKey Laboratory of Jilin Province for Zoonosis Prevention and Control, Military Veterinary Institute, Academy of Military Medical SciencesChangchun, ChinaKey Laboratory of Zoonoses, Ministry of EducationChangchun, ChinaToxoplasma gondii has been suggested as an important opportunistic pathogen in immunocompromised patients. We conducted a global meta-analysis to assess the prevalence and odds ratios (ORs) of T. gondii infection in immunocompromised individuals. Electronic databases were reviewed for T. gondii infection in HIV/AIDS patients, cancer patients, and transplant recipients, and meta-analyses were conducted to calculate overall estimated prevalence and ORs using random or fixed-effects models. Totally, 72 eligible studies were included. The estimated pooled prevalence of T. gondii infection in immunocompromised patients and the control was 35.9 and 24.7% (p < 0.001), with an OR of 2.24, i.e., 42.1 and 32.0% for HIV/AIDS patients and the control (p < 0.05), 26.0 and 12.1% for cancer patients and the control (p < 0.001), and 42.1 and 34.5% for transplant recipients and the control (p > 0.05), whose estimated pooled ORs were 1.92 (95% CI, 1.44–2.55), 2.89 (95% CI, 2.36–3.55), and 1.51 (95% CI, 1.16–1.95), respectively. This study is the first to demonstrate that the immunocompromised patients are associated with higher odds of T. gondii infection, and appropriate prevention and control measures are highly recommended for these susceptible populations.http://journal.frontiersin.org/article/10.3389/fmicb.2017.00389/fullToxoplasma gondiiimmunocompromised patientsHIV/AIDS patientscancer patientstransplant recipientsprevalence |
| spellingShingle | Ze-Dong Wang Ze-Dong Wang Ze-Dong Wang Huan-Huan Liu Zhan-Xi Ma Hong-Yu Ma Zhong-Yu Li Zhi-Bin Yang Xing-Quan Zhu Bin Xu Feng Wei Quan Liu Quan Liu Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis Frontiers in Microbiology Toxoplasma gondii immunocompromised patients HIV/AIDS patients cancer patients transplant recipients prevalence |
| title | Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis |
| title_full | Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis |
| title_fullStr | Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis |
| title_short | Toxoplasma gondii Infection in Immunocompromised Patients: A Systematic Review and Meta-Analysis |
| title_sort | toxoplasma gondii infection in immunocompromised patients a systematic review and meta analysis |
| topic | Toxoplasma gondii immunocompromised patients HIV/AIDS patients cancer patients transplant recipients prevalence |
| url | http://journal.frontiersin.org/article/10.3389/fmicb.2017.00389/full |
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