Progress in the application of ovarian and fallopian tube organoids
As an innovative in vitro culture model, organoids have been established by cell sorting and subsequent culture in three-dimensional culture systems. Organoids can be derived from induced pluripotent stem cells or organ-restricted adult stem cells. Compared with traditional two-dimensional cell cult...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2021-01-01
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| Series: | Reproductive and Developmental Medicine |
| Subjects: | |
| Online Access: | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2021;volume=5;issue=3;spage=174;epage=182;aulast=Dai |
| _version_ | 1828469284629643264 |
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| author | Yi-Lin Dai Jin-Song Wei Jing Xu Ke Li Jing Wang Ran-Ran Cha Yu Kang |
| author_facet | Yi-Lin Dai Jin-Song Wei Jing Xu Ke Li Jing Wang Ran-Ran Cha Yu Kang |
| author_sort | Yi-Lin Dai |
| collection | DOAJ |
| description | As an innovative in vitro culture model, organoids have been established by cell sorting and subsequent culture in three-dimensional culture systems. Organoids can be derived from induced pluripotent stem cells or organ-restricted adult stem cells. Compared with traditional two-dimensional cell culture models and patient-derived xenograft models, organoids possess long-term genetic stability and can better retain the characteristics of source tissues or organs. These advantages have led to the increased use of ovarian and fallopian tube organoids in various fields of research, including cell differentiation and development, establishment of disease occurrence and progression models, tissue regeneration and reconstruction, individual drug screening, immune cell co-culture, and maternal–fetal medicine. This review briefly summarizes the recent progress in the application of ovarian and fallopian tube organoids in the field of obstetrics and gynecology. |
| first_indexed | 2024-12-11T04:36:50Z |
| format | Article |
| id | doaj.art-dd1850214962425cae1fab1f44acc467 |
| institution | Directory Open Access Journal |
| issn | 2096-2924 2589-8728 |
| language | English |
| last_indexed | 2024-12-11T04:36:50Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Reproductive and Developmental Medicine |
| spelling | doaj.art-dd1850214962425cae1fab1f44acc4672022-12-22T01:20:43ZengWolters Kluwer Health/LWWReproductive and Developmental Medicine2096-29242589-87282021-01-015317418210.4103/2096-2924.322840Progress in the application of ovarian and fallopian tube organoidsYi-Lin DaiJin-Song WeiJing XuKe LiJing WangRan-Ran ChaYu KangAs an innovative in vitro culture model, organoids have been established by cell sorting and subsequent culture in three-dimensional culture systems. Organoids can be derived from induced pluripotent stem cells or organ-restricted adult stem cells. Compared with traditional two-dimensional cell culture models and patient-derived xenograft models, organoids possess long-term genetic stability and can better retain the characteristics of source tissues or organs. These advantages have led to the increased use of ovarian and fallopian tube organoids in various fields of research, including cell differentiation and development, establishment of disease occurrence and progression models, tissue regeneration and reconstruction, individual drug screening, immune cell co-culture, and maternal–fetal medicine. This review briefly summarizes the recent progress in the application of ovarian and fallopian tube organoids in the field of obstetrics and gynecology.http://www.repdevmed.org/article.asp?issn=2096-2924;year=2021;volume=5;issue=3;spage=174;epage=182;aulast=Daiorganoid; personalized therapy; stem cell; three-dimensional culture |
| spellingShingle | Yi-Lin Dai Jin-Song Wei Jing Xu Ke Li Jing Wang Ran-Ran Cha Yu Kang Progress in the application of ovarian and fallopian tube organoids Reproductive and Developmental Medicine organoid; personalized therapy; stem cell; three-dimensional culture |
| title | Progress in the application of ovarian and fallopian tube organoids |
| title_full | Progress in the application of ovarian and fallopian tube organoids |
| title_fullStr | Progress in the application of ovarian and fallopian tube organoids |
| title_full_unstemmed | Progress in the application of ovarian and fallopian tube organoids |
| title_short | Progress in the application of ovarian and fallopian tube organoids |
| title_sort | progress in the application of ovarian and fallopian tube organoids |
| topic | organoid; personalized therapy; stem cell; three-dimensional culture |
| url | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2021;volume=5;issue=3;spage=174;epage=182;aulast=Dai |
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