A Thermophilic Phage Endolysin Fusion to a Clostridium perfringens-Specific Cell Wall Binding Domain Creates an Anti-Clostridium Antimicrobial with Improved Thermostability

A Thermophilic Phage Endolysin Fusion to a Clostridium perfringens-Specific Cell Wall Binding Domain Creates an Anti-Clostridium Antimicrobial with Improved Thermostability

Clostridium perfringens is the third leading cause of human foodborne bacterial disease and is the presumptive etiologic agent of necrotic enteritis among chickens. Treatment of poultry with antibiotics is becoming less acceptable. Endolysin enzymes are potential replacements for antibiotics. Man...

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Bibliographic Details
Main Authors: Steven M. Swift, Bruce S. Seal, Johnna K. Garrish, Brian B. Oakley, Kelli Hiett, Hung-Yueh Yeh, Rebekah Woolsey, Kathleen M. Schegg, John Eric Line, David M. Donovan
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Viruses
Subjects:
alternative antimicrobial
bacteriophage
endolysin
food safety
feed additive
peptidoglycan hydrolase
thermostabile
thermostable
Online Access:http://www.mdpi.com/1999-4915/7/6/2758

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