Analysis of the results of the mantoux test with 2 TE in children with rheumatoid arthritis when prescribing genetically engineered drugs
Questions of early detection of tuberculosis infection in children with rheumatoid arthritis (RA) are of particular relevance when prescribing basic therapy with genetically engineered biological drugs (GEBD). At the same time, all of them are at twice the risk of tuberculosis, both for the dis...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Association of Paediatric Allergists and Immunologists of Russia (APAIR)
2023-03-01
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| Series: | Аллергология и Иммунология в Педиатрии |
| Subjects: | |
| Online Access: | https://adair.elpub.ru/jour/article/view/7 |
| _version_ | 1797768096610516992 |
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| author | M. V. Uraksina E. A. Amosova B. E. Borodulin |
| author_facet | M. V. Uraksina E. A. Amosova B. E. Borodulin |
| author_sort | M. V. Uraksina |
| collection | DOAJ |
| description | Questions of early detection of tuberculosis infection in children with rheumatoid arthritis (RA) are of particular relevance when prescribing basic therapy with genetically engineered biological drugs (GEBD). At the same time, all of them are at twice the risk of tuberculosis, both for the disease itself and for the treatment used. The article presents the results of a survey of 121 children aged 1 to 7 years. Two groups were formed: the first group (main group) included 53 patients with rheumatoid arthritis, and the second (comparison group) — 68 children without rheumatoid arthritis. A comparative analysis of the data from the annual Mantoux test was carried out, an additional test with Diaskintest was conducted for differential diagnosis of vaccine and infectious allergies, and risk factors for tuberculosis were studied.In children with JIA, an ineffective BCG vaccination is more often observed, the size of the scar significantly differs in smaller sizes. When evaluating the samples, low sensitivity to tuberculin in the Mantoux test with 2 TE prevails over moderate and high compared with the control group. In a comparative analysis of tuberculosis risk factors, social factors were almost the same (37.7%—32.3%, respectively).The use of Diaskintest excludes active tuberculosis infection in case of negative results, expanding the possibilities for prescribing GEBD in children with RA. |
| first_indexed | 2024-03-12T20:49:38Z |
| format | Article |
| id | doaj.art-dd1a34788baa4f69935dca1170c31594 |
| institution | Directory Open Access Journal |
| issn | 2500-1175 2712-7958 |
| language | Russian |
| last_indexed | 2024-03-12T20:49:38Z |
| publishDate | 2023-03-01 |
| publisher | Association of Paediatric Allergists and Immunologists of Russia (APAIR) |
| record_format | Article |
| series | Аллергология и Иммунология в Педиатрии |
| spelling | doaj.art-dd1a34788baa4f69935dca1170c315942023-08-01T07:30:44ZrusAssociation of Paediatric Allergists and Immunologists of Russia (APAIR)Аллергология и Иммунология в Педиатрии2500-11752712-79582023-03-0101444810.24411/2500-1175-2020-100026Analysis of the results of the mantoux test with 2 TE in children with rheumatoid arthritis when prescribing genetically engineered drugsM. V. Uraksina0E. A. Amosova1B. E. Borodulin2Samara State Medical University of the Ministry of Health of the Russia FederationSamara State Medical University of the Ministry of Health of the Russia FederationSamara State Medical University of the Ministry of Health of the Russia FederationQuestions of early detection of tuberculosis infection in children with rheumatoid arthritis (RA) are of particular relevance when prescribing basic therapy with genetically engineered biological drugs (GEBD). At the same time, all of them are at twice the risk of tuberculosis, both for the disease itself and for the treatment used. The article presents the results of a survey of 121 children aged 1 to 7 years. Two groups were formed: the first group (main group) included 53 patients with rheumatoid arthritis, and the second (comparison group) — 68 children without rheumatoid arthritis. A comparative analysis of the data from the annual Mantoux test was carried out, an additional test with Diaskintest was conducted for differential diagnosis of vaccine and infectious allergies, and risk factors for tuberculosis were studied.In children with JIA, an ineffective BCG vaccination is more often observed, the size of the scar significantly differs in smaller sizes. When evaluating the samples, low sensitivity to tuberculin in the Mantoux test with 2 TE prevails over moderate and high compared with the control group. In a comparative analysis of tuberculosis risk factors, social factors were almost the same (37.7%—32.3%, respectively).The use of Diaskintest excludes active tuberculosis infection in case of negative results, expanding the possibilities for prescribing GEBD in children with RA.https://adair.elpub.ru/jour/article/view/7rheumatoid arthritistuberculosismycobacterium tuberculosislatent tuberculosis infectionimmunity |
| spellingShingle | M. V. Uraksina E. A. Amosova B. E. Borodulin Analysis of the results of the mantoux test with 2 TE in children with rheumatoid arthritis when prescribing genetically engineered drugs Аллергология и Иммунология в Педиатрии rheumatoid arthritis tuberculosis mycobacterium tuberculosis latent tuberculosis infection immunity |
| title | Analysis of the results of the mantoux test with 2 TE in children with rheumatoid arthritis when prescribing genetically engineered drugs |
| title_full | Analysis of the results of the mantoux test with 2 TE in children with rheumatoid arthritis when prescribing genetically engineered drugs |
| title_fullStr | Analysis of the results of the mantoux test with 2 TE in children with rheumatoid arthritis when prescribing genetically engineered drugs |
| title_full_unstemmed | Analysis of the results of the mantoux test with 2 TE in children with rheumatoid arthritis when prescribing genetically engineered drugs |
| title_short | Analysis of the results of the mantoux test with 2 TE in children with rheumatoid arthritis when prescribing genetically engineered drugs |
| title_sort | analysis of the results of the mantoux test with 2 te in children with rheumatoid arthritis when prescribing genetically engineered drugs |
| topic | rheumatoid arthritis tuberculosis mycobacterium tuberculosis latent tuberculosis infection immunity |
| url | https://adair.elpub.ru/jour/article/view/7 |
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